Results 271 to 280 of about 4,742,503 (345)

Contemporary Surgical Management of Colorectal Cancer in Lynch Syndrome: Considering the Implications of Known Genotype

open access: yesANZ Journal of Surgery, EarlyView.
Contemporary surgical management of colorectal cancer in lynch syndrome: considering the implications of known genotype. ABSTRACT Background Lynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in mismatch repair (MMR) genes, accounting for 1%–3% of all colorectal cancer (CRC) diagnoses.
Ashley Jenkin, Kim‐Chi Phan‐Thien
wiley   +1 more source

Long‐term outcomes of fertility‐sparing treatment in endometrial carcinoma and endometrial intraepithelial neoplasia: Recurrence risk factors over a 9‐year follow‐up

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
Fertility‐sparing treatment demonstrated a 62.5% recurrence rate at 10 years. Recurrence was more likely in patients initially treated with megestrol acetate or those with a family history of cancer. As most patients lacked high‐risk molecular features, conservative treatment may remain a safe option for selected individuals under close long‐term ...
Ya‐Ting Hsu   +4 more
wiley   +1 more source

A characteristic gene expression profile regulated by ACIN1::NUTM1 fusion in a newly identified infant leukaemic cell line and an ACIN1::NUTM1‐inducible model

open access: yesBritish Journal of Haematology, EarlyView.
An ACIN1::NUTM1‐positive ALL cell line, KOPN32, which was previously established from a relapsed infant‐ALL case, was newly identified. Comparison using 94 BCP‐ALL cell lines, an ACIN1::NUTM1‐inducible ALL model and clinical sample data revealed upregulation of HOXA9, HOXA10, SKIDA1 and BMI1, indicating direct involvement of ACIN1::NUTM1 fusion in the ...
Minori Tamai   +13 more
wiley   +1 more source

A study of oral metformin for the intravesical treatment of non‐muscle‐invasive bladder cancer

open access: yesBJU International, EarlyView.
Objectives To evaluate the effect of metformin on non‐muscle‐invasive bladder cancer (NMIBC) marker lesions. Patients and methods A phase II, open‐label, multicentre, marker lesion trial using oral metformin in patients with primary or recurrent, multiple, low‐grade Ta‐T1 NMIBC was conducted. After transurethral resection for histological confirmation,
Jons W. van Hattum   +12 more
wiley   +1 more source

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