Bioinformatics and machine learning-based identification of cell cycle-related genes and molecular subtypes in endometrial cancer [PDF]
Jingying Pan +13 more
openalex +1 more source
Cancer Science, EarlyView.This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida +11 more
wiley +1 more source
Identification of Key Genes Involved in the Occurrence and Development of Endometrial Cancer. [PDF]
Int J Womens HealthHuang M, Zhu Q, Tan K, Chen X.
europepmc +1 more source
A machine learning-based immune response signature to facilitate prognosis prediction in patients with endometrial cancer [PDF]
Xiaofeng Wang +12 more
openalex +1 more source
Cancer Science, EarlyView.CXCL1 secreted by M2 macrophages induced EMT of EC cells through the CXCR2/NF‐κB pathway; CXCR2 expression was predominantly observed in the epithelial compartment, whereas CXCL1 expression was primarily localized in the stromal region; Neutralization of M2 macrophage‐secreted CXCL1 and inhibiting the NF‐κB pathway can inhibit EC progression in vivo ...
Ruiqi Xia +4 more
wiley +1 more source
Boswellic Acid Enhances Gemcitabine's Inhibition of Hypoxia-Driven Angiogenesis in Human Endometrial Cancer. [PDF]
Medicina (Kaunas)Alkan Akalın S +4 more
europepmc +1 more source
Variability in Sentinel Lymph Node Locations in Endometrial Cancer: A Single-Center Study and Literature Review [PDF]
Wiktor Szatkowski +6 more
openalex +1 more source
Cancer Science, EarlyView.In this study, we investigated the predictive value of tumor mutational burden (TMB) for assessing the efficacy of pembrolizumab in a Japanese cohort. We analyzed real‐world data from 63,952 patients registered in the C‐CAT database who underwent comprehensive genomic profiling, and evaluated the therapeutic efficacy of pembrolizumab in 1899 of these ...
Tomoyo Yasuda +7 more
wiley +1 more source
Emerging drug delivery approach using nanomaterials for the treatment of endometrial cancer. [PDF]
Front Med TechnolMiao Z +7 more
europepmc +1 more source
Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions
Clinical Endocrinology, EarlyView.ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley +1 more source