Results 121 to 130 of about 1,539,771 (384)

Repurposing metformin for cancer treatment: current clinical studies. [PDF]

, 2016
In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer molecular mechanisms of metformin including mTOR inhibition, cytotoxic ...
Altman, Jessica K, Arya, Ayush, Carneiro, Benedito, Chae, Young Kwang, Chandra, Sunandana, Giles, Francis, Kalyan, Aparna, Kaplan, Jason, Malecek, Mary-Kate, Platanias, Leonidas, Shin, Daniel Sanghoon   +10 more
core   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

CYLD expression in endometrial carcinoma and correlation with clinicohistopathological parameters

Taiwanese Journal of Obstetrics & Gynecology, 2022
Objective: Endometrial cancer is a threat to women health worldwide. Cylindromatosis (CYLD) enzyme is a tumour suppressor, considered an effective prognostic marker in various malignancies, but its role in endometrial carcinoma is not fully elucidated ...
Vasiliki Papadatou, Stylianos Tologkos, Avgi Tsolou, Theodora-Eleftheria Deftereou, Anastasios Liberis, Grigorios Trypsianis, Triantafyllos Alexiadis, Kyriaki Georgiadi, Christina-Angelika Alexiadi, Christina Nikolaidou, Maria Lambropoulou   +10 more
doaj  

Image-Guided High-Dose Rate Intracavitary Brachytherapy in the Treatment of Medically Inoperable Early-Stage Endometrioid Type Endometrial Adenocarcinoma [PDF]

, 2017
To report the experience with high dose rate, image guided intracavitary brachytherapy in the treatment of medically inoperable, early stage endometrial cancer.
Ferriss, MD, J. Stuart, Hernandez, MD, Enrique, Jordan, MD, Scott E., Li, PhD, Shidong, Micaily, MD, Bizhan, Micaily, MD, Ida, Miyamoto, MD, FACR, Curtis T.   +6 more
core   +3 more sources

Endometrial Carcinoma: Role of Current and Emerging Biomarkers in Resolving Persistent Clinical Dilemmas.

American Journal of Clinical Pathology, 2016
OBJECTIVES Type II and other high-grade endometrial carcinomas may challenge conventional treatment due to recurrence and metastatic spread and therefore are a persistent clinical dilemma. Effective targeted therapy for these is a goal for clinicians and
Tatiana N. Buhtoiarova, Carol A. Brenner, Meenakshi Singh   +2 more
semanticscholar   +1 more source

Understanding delays in breast cancer diagnosis in Africa: Key insights and contributing factors

International Journal of Cancer, EarlyView.
What's New? Despite lower incidence rates, Africa has the highest age‐standardized breast cancer mortality rates globally. Using Bronfenbrenner's ecological model to classify multilevel influences on the individual, this scoping review shows that a lack of knowledge about breast cancer is the primary factor contributing to breast cancer diagnostic ...
Liza A. Hoveling, Lynn P. Heuken, Thachita Harfst, Melinda S. Schuurman, Kristel M. van Asselt, Sabine Siesling, Christina Bode   +6 more
wiley   +1 more source

Isolated Small Bowel Metastasis of Endometrial Carcinoma with Resultant Jejunojejunal Intussusception: A Case Report

대한영상의학회지, 2022
Endometrial carcinoma is a common gynecologic malignancy; however, metastasis to the small bowel is rare. Metastatic endometrial carcinoma usually occurs through local extension rather than distant metastasis.
Yeon Jang, Dong Hee Park, Joon Seog Kong
doaj   +1 more source

Present status and future direction of clinical trials in advanced endometrial carcinoma [PDF]

, 2008
Endometrial adenocarcinoma is staged surgically, and advanced endometrial carcinoma is considered to be FIGO stage III and IV. The Gynecologic Oncology Group (GOG) has come a long way in developing new strategies in the management of advanced endometrial
Fleming, Gibbons, Homesley, Howard D. Homesley, Lincoln, Randall, Reisinger, Soper, Sutton, Thigpen   +9 more
core   +2 more sources

Environment, lifestyle, and cancer in women

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Environmental and lifestyle factors significantly contribute to gynecological cancers. The risk of ovarian cancer, one the most lethal gynecological cancer, is associated with obesity, poor dietary habits, and environmental pollutants, exacerbating hormonal imbalances, inflammation, and oxidative stress.
Sara Farina, Alessandra Sabatelli, Stefania Boccia, Giovanni Scambia   +3 more
wiley   +1 more source

Identification of HSPA8 as a candidate biomarker for endometrial carcinoma by using iTRAQ-based proteomic analysis

OncoTargets and Therapy, 2016
Although there are advances in diagnostic, predictive, and therapeutic strategies, discovering protein biomarker for early detection is required for improving the survival rate of the patients with endometrial carcinoma.
N. Shan, W. Zhou, Shufen Zhang, Yu Zhang
semanticscholar   +1 more source