Results 181 to 190 of about 679 (269)

Constipation and urinary retention caused by a vaginal epithelial inclusion cyst in a 1 year old intact cat

Veterinary Record Case Reports, EarlyView.
Abstract This case report describes a rare instance of a keratinising vaginal epithelial inclusion cyst causing significant clinical signs in a 1‐year‐old domestic shorthair queen. The cat presented with severe constipation, urinary retention and a caudal abdominal/cranial intrapelvic mass identified on diagnostic imaging.
Kyle L. Granger Jr., Paula Yoon, Jesse Johnson, Max Paulson, Megan Stadler, Andrea K. Erickson   +5 more
wiley   +1 more source

Job Stress, Psychological Distress, and Menstruation‐Related Symptoms in Female Workers: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective This study examined the relative contributions of mediation and interaction by psychological distress to the association between job stressors and menstruation‐related symptoms. Design A cross‐sectional study. Setting Online survey in August 2023.
Natsu Sasaki, Kazuhiro Watanabe, Miho Egawa, Yuka Ito, Yoshiaki Kanamori, Rikako Tsuji, Mako Iida, Daisuke Nishi   +7 more
wiley   +1 more source

The Demographics and Outcomes of Women With Stage II Endometrial Cancer Diagnosed in Australia 2005–2007

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Stage II endometrial cancer comprises 5% to 10% of cases and is pathologically diverse. Retrospective data guides recommendations which suggest surgical staging with adjuvant therapy, but the role of radical surgery and lymphadenectomy is uncertain, due to conflicting outcomes.
Jonathan Sandeford, Pearl Tong, Selvan Pather   +2 more
wiley   +1 more source

Non‐Allergic Urticarial Skin Reactions Associated With MOv18 IgE, a First‐In‐Class IgE Antibody Recognising Folate Receptor Alpha

Allergy, EarlyView.
MOv18 IgE, the first‐in‐class IgE antibody targeting the cancer antigen folate receptor alpha (FR⍺) showed early signs of efficacy and was well tolerated in a first‐in‐human clinical trial, with transient urticarial skin reactions as the most common toxicity.
Chara Stavraka, Jitesh Chauhan, Silvia Crescioli, Sheila M. McSweeney, Amy Pope, Cheryl Gillett, Ashley Di Meo, Ioannis Prassas, Roman Laddach, Katie Stoker, Alexandra J. McCraw, Rebecca Adams, Thomas J. Tull, Nabeel Naban, Zena Willsmore, Kristina V. Semkova, Clive E. H. Grattan, John McGrath, Stephen J. Till, Christopher J. Corrigan, Rebecca Kristeleit, Sophia Tsoka, Eleftherios P. Diamandis, Katie E. Lacy, Sarah Pinder, Debra H. Josephs, James Spicer, Heather J. Bax, Sophia N. Karagiannis   +28 more
wiley   +1 more source

Magnetic resonance guided high intensity focused ultrasound (MR‐HIFU) effectively reduces fibroid‐related symptoms and improves quality of life—A prospective single‐centre 12‐month follow‐up study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
MR‐HIFU can offer rapid and sustainable symptom relief for selected symptomatic fibroid patients. The severity of fibroid‐related symptoms was significantly reduced at 3 and 12 months, while the quality of life had increased. In addition, the treatment can be offered to women planning future pregnancies, as no negative effect on future fertility or ...
Saara Otonkoski, Antti Viitala, Gaber Komar, Teija Sainio, Anna Yanovskiy, Roberto Blanco Sequieros, Antti Perheentupa, Kirsi Joronen   +7 more
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Risk Stratification Prediction of Endometrial Cancer Using Microstructural Mapping Based on Time‐Dependent Diffusion MRI

Cancer Science, EarlyView.
This work, demonstrating the diagnostic potential of td‐dMRI‐based microstructural mapping in noninvasively probing the pathologic characteristics of patients with EEA in a clinical setting and providing a valuable contribution to surgical guidance, would be of interest to a broad readership in the fields of oncology, preoperative evaluation, and ...
Yu Zhao, Feng Zhao, Meng Cheng, Gang Wang, Dan Wang, Huijuan Yin, Zhixiao Xue, Yule Chen, Zhen Zhao, Hui Ma, Xiaoxiao Zhang, Junping Wang, Fengtan Li   +12 more
wiley   +1 more source

Cancer‐Type‐Specific DNA Methylation Is a Source of Vulnerability in Liver Cancer Cells

Cancer Science, EarlyView.
We profiled genome‐wide DNA methylation in 1165 human cancer cell lines representing 25 cancer types and identified 73 genes as potential liver cancer‐specific methylation‐silenced genes. We selected ASNS, BCAT2, FXYD5, and NQO1 genes for further experimental analysis and demonstrated that aberrant methylation of BCAT2 contributes to the vulnerability ...
Karen Minowa, Miho Seki, Yui Nagai, Satoshi Yamashita   +3 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source