Results 131 to 140 of about 56,095 (256)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Endometriosis and adverse pregnancy outcomes in primiparous women: a retrospective cohort study. [PDF]

Arch Gynecol Obstet
Téoule J, Zikarsky L, Bundschu K, Andres S, Hancke K.   +4 more
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Emerging Non-Pharmacological Approaches in Endometriosis: Mechanistic Insights into Phototherapy, Hyperthermia, and Acupuncture-Literature Review. [PDF]

J Clin Med
Szukalska I, Ziętek M, Zagrodnik E, Szczuko M.   +3 more
europepmc   +1 more source

Endometriosis-Associated Infertility: A Review of Pathophysiological Mechanisms and Current Treatment Strategies. [PDF]

J Clin Med
Gniadek M, Porubenska A, Pełka K, Rzepkowska Z, Florjański J.   +4 more
europepmc   +1 more source

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

Cell Proliferation, EarlyView.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge, Chenxiang Zhang, Yilong Zhao, Haiyang Zhao, Shuai Zhu, Tao Tang, Guorui Zhang, Qiang Wang, Hui Wang   +8 more
wiley   +1 more source

The Microbiota-Endometriosis Axis: An Immune-Endocrine Integration Model and Emerging Therapeutic Targets. [PDF]

Int J Mol Sci
Nemeti G, Crăciun AE, Măgureanu DC, Militaru FC, Bocsan IC, Crăciun CI, Rusu A, Melincovici CS, Buzoianu AD, Mureșan D, Neag MA.   +10 more
europepmc   +1 more source

Three‐Dimensional Architecture of Ectopic Epithelium and Vasculature in Ovarian Endometriosis Revealed by Tissue‐Clearing Imaging

Cell Proliferation, EarlyView.
Our study employed a modified tissue‐clearing method combined with deep imaging for 3D reconstruction of ovarian endometriosis (OEM) lesions, revealing its morphological polymorphism at tissue and cellular levels. Besides, vessels preferentially clustered around the ectopic epithelium, with their distribution pattern strongly linked to the location of ...
Fanyuan Sun, Shuzhen Wang, Jinyan Zhao, Jinhua Leng, Xili Zhu, Chongdong Liu, Jing Chen, Jinming Guo, Bangjing Jiang, Haihe Zhou, Zhuoying Li, Hua Li, Menghui Li, Yongcun Qu   +13 more
wiley   +1 more source

The Impact of Endometriosis on Ovarian Reserve: A Systematic Review. [PDF]

Int J Womens Health
Christina NLL, Tjahyadi D, Anwar R, Rachmawati A, Rafi MA.   +4 more
europepmc   +1 more source

Lived Experiences of Pregnancy Loss at Work: Realizing Meaningful Supports

Gender, Work &Organization, EarlyView.
ABSTRACT There is increased focus on pregnancy loss at work over recent years, with many countries introducing or exploring the introduction of statutory leave for pregnancies that end pre‐“viability.” Individual organizations are also introducing their own pregnancy loss policies.
Marita Hennessy, Tamara Escañuela Sánchez, Sara Leitao, Ruadh Kelly‐Harrington, Maeve O'Sullivan, Caroline Dalton‐O’Connor, Mary Donnelly, Claire Murray, Daniel Nuzum, Keelin O'Donoghue   +9 more
wiley   +1 more source