Results 151 to 160 of about 159,563 (339)
International Journal of Cancer, EarlyView.What's New? High‐grade serous ovarian carcinoma is often diagnosed at advanced stages due to non‐specific symptoms and the lack of reliable screening methods. This proof‐of‐concept study introduces a novel TP53 mutation panel using unique molecular identifier‐based next‐generation sequencing for sensitive detection of high‐grade serous ovarian ...
Amanda Olsson Widjaja +11 more
wiley +1 more source
Living at genetic risk: The patient experience of Lynch syndrome
International Journal of Cancer, EarlyView.Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents +2 more
wiley +1 more source
The Inhibitory Effect of Noscapine on the In Vitro Cathepsin G-Induced Collagen Expression in Equine Endometrium [PDF]
, 2021 Ana Amaral +7 more
openalex +1 more source
International Journal of Cancer, EarlyView.Abstract Deficiency in DNA mismatch repair (dMMR) is a common pathway of carcinogenesis across different tumor types and confers a characteristic microsatellite instability‐high (MSI‐H) molecular phenotype. The MSI‐H/dMMR phenotype may arise from an inherited pathogenic variant in the context of Lynch syndrome and is most frequently observed in ...
Martin Duval +8 more
wiley +1 more source
Pubertal timing and incident uterine cancer in the Sister Study cohort
International Journal of Cancer, EarlyView.What's New? Younger age at menarche is an established risk factor for uterine cancer. Age at onset of breast development (thelarche), the earliest marker of pubertal estrogen exposure unopposed by progesterone, may also be relevant to uterine cancer risk, but this association has not been explored. Using data from the US prospective Sister Study cohort,
Ariayana N. Harrell +4 more
wiley +1 more source
International Journal of Cancer, EarlyView.What's New? The DNA methylation‐based WID‐qEC test has been validated for the accurate detection of endometrial and cervical cancers using cervico‐vaginal samples. However, a small proportion of women test positive despite the absence of these cancers. This study explored the associated biological and clinical characteristics to inform potential follow‐
Elisa Redl +18 more
wiley +1 more source
Diagnostic Pathology, 2009 Background Different molecular alterations have been described in endometrioid endometrial carcinoma (EECA). Among them the most frequently altered is loss of the PTEN protein, a tumor suppressor gene.
Sotoudeh Kambiz +3 more
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