Results 191 to 200 of about 210,784 (393)

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

Effects of intrauterine infusion of iodine solution, on the estrous cycle of the cow. I. Modification of the estrous cycle length and inflammatory response of the endometrium to the treatment

, 1967
Tatsuo Nakahara, Ikuo Domeki, S. Inui, Makoto YAMAUCHI   +3 more
openalex   +2 more sources

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Radioautographic Evaluation of Mitotic Parameters in the Endometrium During the Uterine Sensitivity Period in the Pseudopregnant Rat

, 1969
Leroy F. Liu, P. Galand
openalex   +1 more source

Integrative omics approaches to uncover liquid‐based cancer‐predicting biomarkers in Lynch syndrome

International Journal of Cancer, EarlyView.
What's New? Lynch syndrome (LS) significantly increases lifetime cancer risk, necessitating innovative approaches for risk stratification. Current risk assessment methods, however, fail to integrate data from different biological systems, which may be influenced by lifestyle factors.
Minta Kärkkäinen, Tero Sievänen, Tia‐Marje Korhonen, Joonas Tuomikoski, Kirsi Pylvänäinen, Sami Äyrämö, Toni T. Seppälä, Jukka‐Pekka Mecklin, Eija K. Laakkonen, Tiina Jokela   +9 more
wiley   +1 more source

Embryo-maternal cross-talk: key players in successful implantation and live birth rates. [PDF]

Reprod Biol Endocrinol
Karimi S, Baharaghdam S, Danaii S, Yousefi M.   +3 more
europepmc   +1 more source

Glycogen, Glycogen-Metabolizing Enzymes, and Acid And Alkaline Phosphatases in the Endometrium of the Ewe During Early Pregnancy [PDF]

, 1970
RN Murdoch
openalex   +1 more source

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, EarlyView.
What's New? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

Single-cell RNA sequencing of endometrium uncovers dynamic characteristics and dysregulation of perivascular CD9⁺SUSD2⁺ cells in thin endometrium. [PDF]

Stem Cell Res Ther
Liang B, Qi L, Chen M, Mai C, Diao L, Ding L, Zhang T, Chen X.   +7 more
europepmc   +1 more source

Potential Changes in the Eutopic Endometrium in Endometriosis: A Narrative Review. [PDF]

Cureus
Makrygiannakis F, Vrekoussis T, Berdiaki A, Makrigiannakis A.   +3 more
europepmc   +1 more source