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The Cmr complex: an RNA-guided endoribonuclease
Biochemical Society Transactions, 2013The CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated) system protects prokaryotes from infection by viruses and other potential genome invaders. This system represents an inheritable and adaptable immune system that is mediated by large ribonucleoprotein complexes, the CRISPR–Cas effector complexes.
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Chapter 16 Staphylococcus aureus Endoribonuclease III
2008Staphylococcus aureus ribonuclease III (Sa-RNase III) belongs to the enzyme family known to process double-stranded RNAs consisting of two turns of the RNA helix. Although the enzyme is thought to play a role in ribosomal RNA processing and gene regulation, the deletion of the rnc gene in S. aureus does not affect cell growth in rich medium. S.
Sandrine Boisset +7 more
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Endoribonuclease from bovine adrenal cortex cytosol
Biochemistry, 1975An endoribonuclease which digests a variety of synthetic homoribopolymers and poly(A)-rich mRNA has been identified and purified greater than 500-fold with respect to specific activity from bovine adrenal cortex cytosol. Enzymatic digestion of synthetic poly(riboadenylic acid) was stimulated by Mn-2+ and Mg-2+ and the enzyme exhibited broad pH and salt
Henry I. Miller +2 more
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Structure and function of Zucchini endoribonuclease in piRNA biogenesis
Nature, 2012PIWI-interacting RNAs (piRNAs) silence transposons to maintain genome integrity in animal germ lines. piRNAs are classified as primary and secondary piRNAs, depending on their biogenesis machinery. Primary piRNAs are processed from long non-coding RNA precursors transcribed from piRNA clusters in the genome through the primary processing pathway ...
Miharu K. Kamatani +16 more
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Cleavage site recognition by the tRNA splicing endoribonuclease
Gene, 1993A single tRNA-splicing endoribonuclease can cleave several precursors. In addition to the conserved nucleotides (nt), there are positions in the mature domain that, though not always occupied by the same nt, nevertheless play a fundamental role in intron excision reaction. The elements of the recognition set (invariant nt, nt at the cardinal positions)
M. Irene Baldi +3 more
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Endoribonuclease activity associated with animal RNA viruses
Journal of Virology, 1978A specific endoribonucleolytic activity was detected when detergent-lysed vesicular stomatitis of Sendai virus was incubated with the precursor to Escherichia coli tRNA Tyr. The cleavage products produced and the characteristics of the reaction were similar to those previously reported for human KB cell RNase NU.
S Altman, Daniel Kolakofsky
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Endoribonuclease IV. 2. Further Investigation on the Specificity
European Journal of Biochemistry, 1976The poly(A)-specific endoribonuclease IV produces oligo(A) fragments of a chain length of 10 AMP nucleotides. One enzyme molecule performs 1700 cleavages per min; the cleavages occur randomly. The endoribonuclease IV is a nuclear enzyme which is present in the oviduct of quails in a concentration of 40 000 enzyme molecules per cell. Poly(A) segments on
Gerhard Seibert +3 more
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mRNA interferases, sequence-specific endoribonucleases from the toxin-antitoxin systems.
Progress in Molecular Biology and Translational Science, 2009Y. Yamaguchi, M. Inouye
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Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
Nature reviews. Molecular cell biology, 2018T. Treiber, N. Treiber, G. Meister
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