Results 141 to 150 of about 35,092 (349)

Contrast Does Not Affect Cholangioscope Image Quality

open access: yesGut and Liver, 2011
Background/Aims: Peroral cholangioscopy is a rapidly evolving technique that allows direct examination of the bile duct. We sought to determine if there was a difference in image quality with the cholangioscope immersed in normal saline compared with ...
doaj   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

open access: yesAdvanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu   +8 more
wiley   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

open access: yesAdvanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong   +21 more
wiley   +1 more source

Laparoscopic Delivery of a MnO2‐P‐ICG Patch for Photodynamic Therapy and NK Cell‐Driven Immunotherapy in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
This study proposes a flexible MnO2‐P‐ICG nanofiber patch for laparoscopic treatment of liver tumors. The patch alleviates tumor hypoxia and induces photodynamic therapy (PDT) triggered immunogenic cell death, thereby activating the cGAS‐STING pathway and, in synergy with pachymaran, promoting NK cell–mediated innate immunity. This synergistic strategy
Jie Lin   +14 more
wiley   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu   +11 more
wiley   +1 more source

Short Distal Resection Margin Does Not Increase Recurrence Risk After R0 Resection for Rectal Neuroendocrine Tumors: A Single‐Institution Retrospective Study of 208 Patients

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This study evaluated the impact of distal resection margin (DRM) length on recurrence in 208 patients undergoing surgery for rectal neuroendocrine tumors (NETs). Our findings demonstrate that while oncological safety must unquestionably remain the top priority, a short pathological DRM (< 10 mm) does not increase recurrence risk when R0 resection is ...
Kentaro Sato   +8 more
wiley   +1 more source

Efficacy of high-level disinfection of endoscopes contaminated with Streptococcus equi subspecies equi with 2 different disinfectants [PDF]

open access: gold, 2023
Veridiana Nadruz   +5 more
openalex   +1 more source

First Successful Regeneration of a Structurally Native‐Like Colon Using a Bioabsorbable Polymer Sheet

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This study demonstrated that a bioabsorbable polymer sheet (BAPS) can regenerate approximately half the circumference of the colon with native‐like structure and function in an experimental setting. As the model involved immediate closure after perforation and did not reproduce peritonitis, caution is required when considering clinical applicability ...
Junpei Takashima   +4 more
wiley   +1 more source

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