Results 181 to 190 of about 44,363 (283)

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

open access: yesAllergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng   +20 more
wiley   +1 more source

Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model

open access: yesAllergy, EarlyView.
Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang   +13 more
wiley   +1 more source

Emerging Trends in Patients Hospitalised With Cirrhosis—Aetiologies, Complications and Outcomes Compared to Other Chronic Health Conditions

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
Rates of inpatient mortality and complication rates in cirrhosis remain high. With regard to inpatient outcomes, cirrhosis is falling behind other chronic health conditions. ABSTRACT Background The aetiologies, complications and overall burden of cirrhosis have undergone changes in recent years.
Julian Pohl   +9 more
wiley   +1 more source

Temporal Trends in Medical and Surgical Management of Ulcerative Colitis in England: 2003–2020

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
Colectomy rates in ulcerative colitis have declined over the last two decades, coinciding with increased use of advanced therapies. These trends reflect significant changes in treatment approaches and provide valuable data to support informed decision‐making by patients, clinicians, and healthcare providers.
J. Couch   +3 more
wiley   +1 more source

[The therapeutic significance of endoscopy of the digestive system].

open access: yesGaceta medica de Mexico, 1989
J, Ramírez-Degollado   +4 more
openaire   +1 more source

Pacientu sagatavošana gremošanas sistēmas endoskopiskiem izmeklējumiem

open access: yes, 2016
Bakalaura darba tēma: “Pacientu sagatavošana gremošanas sistēmas endoskopiskiem izmeklējumiem”. Tēmas aktualitāti nosaka pēdējos gados veikto pētījumi rezultāti, kas liecina par nepietiekamu pacientu informētības un sagatavotības līmeni gremošanas sistēmas endoskopiskiem izmeklējumiem, kā rezultātā veicinot nekvalitatīvu diagnostisko izmeklējumu un ...
openaire   +1 more source

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