Results 241 to 250 of about 120,309 (318)

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

open access: yesImmunology, Volume 177, Issue 4, Page 736-748, April 2026.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Graft and Patient Survival After Liver Transplantation for Primary Sclerosing Cholangitis: A French National Cohort Study

open access: yesLiver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background A significant proportion of patients presenting a primary sclerosing cholangitis (PSC) will require liver transplantation (LT). The present study aimed to investigate graft loss and patient death in a large cohort of patients. Methods We conducted a nationwide multicenter retrospective study including all adult patients transplanted
Florian Veyre   +35 more
wiley   +1 more source

Care Pathways for Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD): A State‐of‐The‐Art Review

open access: yesLiver International, Volume 46, Issue 4, April 2026.
ABSTRACT Metabolic dysfunction‐Associated Steatotic Liver Disease (MASLD) is a growing clinical challenge, necessitating effective diagnostic strategies to identify advanced liver fibrosis while minimising unnecessary referrals of mild cases. Current clinical guidelines recommend care pathways utilising non‐invasive tests (NITs) to stratify patients ...
Kirsi M. A. van Eekhout   +15 more
wiley   +1 more source

The Ergonomic Comparison of Endoscopist's Hand/Arm Movement and Relevant Muscle Load Between the Diagnostic and Therapeutic Upper Gastrointestinal Endoscopy. [PDF]

open access: yesDig Endosc
Nagano S   +14 more
europepmc   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

open access: yesAdvanced Science, Volume 13, Issue 14, 9 March 2026.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan   +11 more
wiley   +1 more source

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