Results 151 to 160 of about 23,650,103 (189)
Some of the next articles are maybe not open access.
Intrarenal conversion of big endothelin-1 to endothelin-1 in the rat
Life Sciences, 1994Intravenous (i.v.) or intrarenal arterial (i.r.a.) injection of big endothelin-1 (big ET-1) (1.6 nmol/kg) in anesthetized rats produced a significant increase in mean arterial pressure (MAP), a decrease in renal blood flow (RBF) and an increase in renal vascular resistance (RVR). Although the pressor responses to big ET-1 of i.v. and i.r.a.
Katsuya Fujita +5 more
openaire +3 more sources
Analytical Biochemistry, 2000
The possible diagnostic or prognostic significance of changes in circulating level of endothelins in a variety of pathological conditions is currently of interest. Unfortunately, no consensus regarding optimization of sensitivity and extraction procedures for the reliable radioimmunoassay of endothelin-1 (ET-1), big endothelin-1 (BigET-1), and ...
Michael C. Schmid +2 more
openaire +3 more sources
The possible diagnostic or prognostic significance of changes in circulating level of endothelins in a variety of pathological conditions is currently of interest. Unfortunately, no consensus regarding optimization of sensitivity and extraction procedures for the reliable radioimmunoassay of endothelin-1 (ET-1), big endothelin-1 (BigET-1), and ...
Michael C. Schmid +2 more
openaire +3 more sources
Endothelin-1 and the Adrenal Gland
Journal of Cardiovascular Pharmacology, 2000Compelling evidence indicates an important role of endothelin (ET)-1 and its receptor subtypes A and B (ET(A) and ET(B)) in the regulation of secretion and growth of the human adrenal gland. ET-1, which is expressed both at the mRNA and at the peptide level in the adrenal cortex, directly stimulates aldosterone secretion in different species, both in ...
ROSSI, GIANPAOLO +3 more
openaire +4 more sources
Endothelin-1 and big endothelin-1 in NIDDM patients with and without microangiopathy
Diabetes Research and Clinical Practice, 1994To examine a possible role for endothelin-1 in the pathophysiology of diabetic microangiopathy, we measured plasma levels of endothelin-1 and big endothelin-1, a precursor peptide of endothelin-1, in 33 untreated patients with non-insulin-dependent diabetes mellitus.
Miyuki Ishibashi +2 more
openaire +3 more sources
Neuroscience, 1999
Neurons likely to use endothelin as a neurotransmitter/neurohormone were mapped in the rat brain using polyclonal antibodies directed against endothelin-converting enzyme-1, endothelin-1, and endothelin-3. Anti-endothelin-converting enzyme-1 antibodies produced the most robust staining, permitting the best visualization of the distribution and ...
J.C Lehmann +4 more
openaire +3 more sources
Neurons likely to use endothelin as a neurotransmitter/neurohormone were mapped in the rat brain using polyclonal antibodies directed against endothelin-converting enzyme-1, endothelin-1, and endothelin-3. Anti-endothelin-converting enzyme-1 antibodies produced the most robust staining, permitting the best visualization of the distribution and ...
J.C Lehmann +4 more
openaire +3 more sources
Nociceptive sensitization by endothelin-1
Brain Research Reviews, 2009The endogenous peptide endothelin-1 (ET-1), originally identified as a potent vasoconstrictor, plays a role in a number of painful conditions. In this review article we discuss the mechanisms that are essential for local sensitization by subcutaneously administered ET-1, and report evidence of ET-1's ability to sensitize distant regions of the body ...
Hans, Guy +2 more
openaire +4 more sources
Comparison of the hemodynamic effects of endothelin-1 and big endothelin-1 in the rat
Biochemical and Biophysical Research Communications, 1991We compared the hemodynamic effects of continuous i.v. infusion of endothelin-1 and big endothelin-1 in anesthetized rats. Big endothelin-1 was fivefold less potent than endothelin-1 in decreasing cardiac output, heart rate, and stroke volume. However, big endothelin-1 produced a significantly larger increase in mean arterial pressure compared to ...
Terry J. Opgenorth, David M. Pollock
openaire +3 more sources
Regional extraction of endothelins and conversion of big endothelin to endothelin‐1 in the pig
Acta Physiologica Scandinavica, 1991Endothelin‐like immunoreactivity (ET‐LI), mean arterial blood pressure (MABP) and vascular resistance in the spleen, kidney and femoral vascular bed were measured during intravenous infusions (20 pmol. kg‐1. min) of endothelin‐2 (ET‐2), endothelin‐3 (ET‐3), big endothelin‐1 (big ET) and sarafotoxin 6b in the pig.
Jan M. Lundberg +2 more
openaire +3 more sources
Intrarenal endothelin-1 and hypertension
American Journal of Kidney Diseases, 2000NDOTHELIN-1 (ET-1) is a 21-amino acid peptide with an order of magnitude greater vasoconstrictive potency than any known endogenous compound. Since its discovery one decade ago, more than 1,500 publications have examined the role of endothelins in the development and maintenance of primary and secondary hypertension.
openaire +4 more sources
Endothelin receptors and endothelin-1 in developing rat teeth
Archives of Oral Biology, 2007The endothelins are a family of small peptides with multiple roles in a variety of tissues. Signaling is mediated through two receptor subtypes, the endothelin A receptor (ET(A)) specific for Et-1 and the non-specific endothelin B receptor (ET(B)).Our goal was to determine the location of immunoreactivity (IR) for ET(A) and ET(B) in developing and ...
Scott J. Neuhaus, Margaret R. Byers
openaire +3 more sources