Results 161 to 170 of about 23,650,103 (189)

Endothelin-1 and endothelin receptors in the basilar artery of the capybara

Journal of Molecular Histology, 2005
Little is known about cerebral vasculature of capybara, which seems may serve as a natural model of studying changes in cerebral circulation due to internal carotid artery atrophy at animal sexual maturation. This is the first study of the light- and electron-immunocytochemical localisation of endothelin-1 (ET-1) and ETA and ETB endothelin receptors in
Loesch, A, Gajkowska, B, Dashwood, MR, Fioretto, ET, Gagliardo, KM, Lima, AR, Ribeiro, AA   +6 more
openaire   +4 more sources

Is Big Endothelin Converted to Endothelin-1 in Circulating Blood?

Journal of Cardiovascular Pharmacology, 1991
Although evidence has been accumulating to support an intracellular processing of big endothelin-1 (big ET-1) to ET-1, molecular conversion in the circulating blood remains to be elucidated. The present study was undertaken to investigate whether big ET-1 was converted to ET-1 in human blood.
Yasuko Watanabe, Mitsuhide Naruse, Chikako Monzen, Kiyoko Naruse, Kazuoki Ohsumi, Junko Horiuchi, Izumi Yoshihara, Yuko Kato, Noriko Nakamura, Mariko Kato, Nobuhiro Sugino, Hiroshi Demura   +11 more
openaire   +3 more sources

The Fate of Radioiodinated Endothelin-1 and Endothelin-3 in the Rat

Journal of Cardiovascular Pharmacology, 1989
Endothelin-1 (ET-1) has been isolated from cultured endothelial cells and might have a role in cardiovascular regulation. To study the fate of labeled ET-1, we prepared [125I]-labeled ET-1 (formerly porcine and human ET) and ET-3 (formerly rat ET). Approximately 0.2 microCi (0.2 pmol) was injected into the left ventricle of anesthetized rats and blood ...
Erik Änggård, Giles Rae, Lorraine McLoughlin, Simon Gallon, Roger Thomas, John R. Vane, Gilberto De Nucci   +6 more
openaire   +3 more sources

Endothelin-1 and endothelin-3 binding to rat nephrons

American Journal of Physiology-Renal Physiology, 1993
The existence of endothelin (ET) receptor subtypes has recently been implicated in the different biological effects of ET in various tissues. Indeed, the cDNAs for two types of ET receptors, ETA and ETB, have been cloned. To further gain insights into ET function in the kidney we examined 125I-labeled ET-1 and ET-3 binding to microdissected rat ...
Etsuro Ogata, Kiyoshi Kurokawa, Shunya Uchida, Fumi Takemoto   +3 more
openaire   +3 more sources

Endothelin-1 and tumour development

European Journal of Surgical Oncology (EJSO), 1998
There has been a growing conviction amongst oncologists that cancer is a disease characterized by changes in specific molecules. These changes include alteration in the structure, regulation or quantity of growth factors and their receptors, signal transducers and the proteins encoded by dominant or suppressor/recessive oncogenes.
Irving Taylor, E.H. Asham, Marilena Loizidou   +2 more
openaire   +3 more sources

Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?

Annals of Internal Medicine, 1991
OBJECTIVE To explore the role of endothelin-1, a potent endothelial-derived vasoconstrictor peptide, in pulmonary hypertension, by measuring its concentration in arterial and venous plasma. DESIGN A survey, case series study.
D. Stewart, R. Levy, P. Cernacek, D. Langleben   +3 more
semanticscholar   +1 more source

The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives.

American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2011
Nitric oxide (NO) and endothelin-1 (ET-1) are natural counterparts in vascular function, and it is becoming increasingly clear that an imbalance between these two mediators is a characteristic of endothelial dysfunction and is important in the ...
Stephane L. Bourque, S. Davidge, M. Adams   +2 more
semanticscholar   +1 more source

Endothelin-1 and Endothelin-3 Stimulate Ovarian Steroidogenesis

Journal of Cardiovascular Pharmacology, 1991
The possible direct involvement of endothelin (ET) in preovulatory follicular steroidogenesis was investigated in vitro. Follicular development in immature rats was induced by pregnant mare's serum gonadotropin (PMS). Twenty-four and 48 h after PMS injection, ovarian follicles were incubated in vitro with or without 4 x 10(-11) to 4 x 10(-5) M ...
Katsutoshi Goto, Satoshi Usuki, Chikako Kitada, Tamotsu Saitoh, Tomoh Masaki, Nobuhiro Suzuki   +5 more
openaire   +3 more sources

The comparative effects of big endothelin-1, endothelin-1, and endothelin-3 in the human fetal-placental circulation

American Journal of Obstetrics and Gynecology, 1992
This study compared the effects of big endothelin-1, endothelin-1, and endothelin-3 and whether endothelin-converting enzyme was present in the human fetal-placental circulation.Single cotyledons of term placentas were dually perfused in vitro, and increases in fetal-placental perfusion pressure to bolus injections of big endothelin-1, endothelin-1 ...
Anthony S. Brewer, Diane E. Brockman, Leslie Myatt   +2 more
openaire   +3 more sources

Downregulation of endothelin receptors by autocrine production of endothelin-1

American Journal of Physiology-Cell Physiology, 1993
The potent vasoconstrictor endothelin-1 (ET-1) is a paracrine, but also autocrine, factor for some types of cells. The goal of our study was to evaluate whether the receptor population in cells expressing endothelin receptor subtype A (rat mesangial cells) or endothelin receptor subtype B (human and rat endothelial cells) was affected by the autocrine
B. Butscha, L. Hilfiger, Jean-Paul Maire, Martine Clozel, Bernd-Michael Löffler, Volker Breu   +5 more
openaire   +3 more sources