Proteostasis Response to Protein Misfolding in Controlled Hypertension
Cells, 2022 Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira +12 more
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Endothelin-1 and antiangiogenesis [PDF]
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2016 Antiangiogenesis, targeting vascular endothelial growth factor (VEGF), has become a well-established treatment for patients with cancer. This treatment is associated with nitric oxide (NO) suppression and a dose-dependent activation of the endothelin system, resulting in preeclampsia-like features, particularly hypertension and renal injury. Studies in
Lankhorst, Stephanie +2 more
openaire +2 more sources
Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin [PDF]
, 2010 Background: Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein ...
Clerk, Angela +5 more
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Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1 [PDF]
, 2004 The influence of diabetes on regulatory mechanisms and specific receptors implicated in the contractile response of isolated rabbit carotid arteries to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was greater
Alabadí Ferrer, José Antonio +4 more
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Serum endothelin-1 level positively correlates with waist and hip circumferences in stable coronary artery disease patients [PDF]
Reviews in Cardiovascular Medicine, 2021 Central obesity is associated with increased level and activity of endothelin-1. The waist and hip circumferences are simple indicators of central obesity.
Anggoro Budi Hartopo +3 more
doaj +1 more source
Truncated human endothelin receptor A produced by alternative splicing and its expression in melanoma [PDF]
, 1998 In this study, reverse transcriptase polymerase chain reaction was used to amplify human endothelin receptor A (ETA) and ETB receptor mRNA. A truncated ETA receptor transcript with exons 3 and 4 skipped was found.
Berry, PA +5 more
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Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes [PDF]
, 2006 The influence of diabetes on regulatory mechanisms and specific receptors implicated in the response of isolated rabbit renal artery to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was less potent in arteries
Alabadí Ferrer, José Antonio +4 more
core +2 more sources
Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition [PDF]
, 2008 Inhibition of glycogen synthase kinase 3β (GSK3β) as a consequence of its phosphorylation by protein kinase B/Akt (PKB/Akt) has been implicated in cardiac myocyte hypertrophy in response to endothelin-1 or phenylephrine.
Alsafi, Ali +7 more
core +1 more source
Endothelin-converting enzyme-1 expression in acute and chronic liver injury in fibrogenesis
Animal Cells and Systems, 2019 Endothelin-1 (ET-1) induces contraction, proliferation, and collagen synthesis of activated hepatic stellate cells and is a potent mediator of portal hypertension.
Tae-Jun Cho, Hyo-Jung Kim, Jaejin Cho
doaj +1 more source
An emerging role for microRNA in the regulation of endothelin-1
Frontiers in Physiology, 2013 Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (
Mollie E Jacobs +3 more
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