Results 211 to 220 of about 141,025 (360)

Phase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment [PDF]

, 2017
A Rai, AG Tolcher, AX Zhu, Caio Max S Rocha-Lima, David Portnoy, DP Brooks, E Gabriela Chiorean, E Suzuki, J Albores-Saavedra, J Nelson, J Valle, JE Rogers, JF Guion-Dussere, Jitendra Gandhi, L Goyal, M Yanagisawa, Manik Amin, NV Rajeshkumar, NV Rajeshkumar, P Papakostas, R Pazdur, Richard Kim, RK Jain, RL Siegel, S He, SC Lee, SY Oh, T Sasaki, T Walter, Tao Song, William P Harris   +30 more
core   +3 more sources

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

[Retracted] Functions of endothelin‑1 in apoptosis and migration in hepatocellular carcinoma. [PDF]

Exp Ther Med
Shi L, Zhou SS, Chen WB, Xu L.
europepmc   +1 more source

Current Challenges in Hemostasis and Advances in Particle‐Assisted Styptic Devices

Advanced Healthcare Materials, Volume 15, Issue 2, 14 January 2026.
Here persistent limitations in hemostatic technologies are highlighted and cutting‐edge biomimetic, microparticle‐assisted, and nanoengineered systems with integrated drug delivery are showcased. Moreover, the article identifies fresh directions toward the next‐generation of multifunctional hemostatic devices with superior efficacy and accessibility ...
Daniele Baiocco, Zhibing Zhang, Neil M. Eisenstein, Nigel Tai, Liam M. Grover   +4 more
wiley   +1 more source

The Biomarker Galaxy: Big Endothelin-1 Joins the Expanding Universe of Heart Failure Prognostication. [PDF]

Korean Circ J
Cho DH.
europepmc   +1 more source

Proteomic Analysis of Endothelin-1 Targets in the Regulation of Cardiomyocyte Proliferation

, 2017
Alexandra Shin, Chiranjib Dasgupta, Guangyu Zhang, Kala Chand Seal, Li Zhang   +4 more
openalex   +1 more source

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation [PDF]

, 2014
Timothy R. Hammond, Ana Gadea, Jeffrey L. Dupree, Christophe Kerninon, Brahim Nait‐Oumesmar, Adán Aguirre, Vittorio Gallo   +6 more
openalex   +1 more source

Tumor‐Derived Interleukin 35 Promotes Fibrosis in the Tumor Microenvironment of Pancreatic Cancer by Activating Pancreatic Stellate Cells

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study demonstrates that tumor‐derived IL‐35 promotes pancreatic cancer fibrosis by indirectly activating pancreatic stellate cells through IGFBP2/IGF‐1R/PI3K‐Akt and Tsp‐1/TGF‐β pathways. IL‐35 blockade reduces stromal fibrosis, restores chemosensitivity, and synergizes with gemcitabine‐based regimens, highlighting IL‐35 as a promising therapeutic
Hui Li, Huizhi Sun, Jing Liu, Yan Wu, Lin Wei, Jianming Li, Yudong Yuan, Peng Xie, Chao Xu, Guolu Luo, Yuqi Guan, Yukuan Feng, Antao Chang, Jihui Hao, Chongbiao Huang   +14 more
wiley   +1 more source

Endothelin-1 signaling in the kidney: recent advances and remaining gaps. [PDF]

Am J Physiol Renal Physiol
Brooks AJ, Gallego-López MDC, De Miguel C.   +2 more
europepmc   +1 more source

The acute effect of high intensity aerobic training on ANP and Endothelin-1 in obese women

, 2017
Rouhollah Haghshenas, Samaneh Nazemian, Mohsen Ebrahimi   +2 more
openalex   +2 more sources