Results 291 to 300 of about 141,025 (360)

Inactivation of BACE2 stimulates release of endothelin-1 from human brain microvascular endothelial cells. [PDF]

J Alzheimers Dis Rep
He T, Katusic ZS.
europepmc   +1 more source

Proteins and signalling pathways targeted by dapagliflozin and finerenone: Insights from DAPA‐CKD and FIGARO‐DKD

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 750-753, January 2026.
Mark André de la Rambelje, Adriaan A. Voors, Peter J. Greasley, Mario Berger, Hiddo J. L. Heerspink   +4 more
wiley   +1 more source

Dietary flavanols preserve upper‐ and lower‐limb endothelial function during sitting in high‐ and low‐fit young healthy males

The Journal of Physiology, Volume 604, Issue 1, Page 145-171, 1 January 2026.
Abstract figure legend Schematic indicating the design of an acute randomised, counterbalanced, double‐blinded, cross‐over, placebo‐controlled human study in which 20 high‐fit males and 20 low‐fit males consumed either a low‐flavanol (5.6 mg) or a high‐flavanol (695 mg) cocoa drink prior to a 2 h uninterrupted sitting bout.
Alessio Daniele, Samuel J. E. Lucas, Catarina Rendeiro   +2 more
wiley   +1 more source

Endothelin-1 Participates in the Pathogenesis of Prurigo Nodularis by Promoting NGF Expression via Endothelial Receptor B in Epidermal Keratinocytes and Dorsal Root Ganglion Cells. [PDF]

Allergy
Wong LS, Yang JL, Yen YT, Lee CH, Yang JH.   +4 more
europepmc   +1 more source

Cardiovascular Dysfunction in Polycystic Ovary Syndrome: Mitochondrial and Inflammatory Mechanisms

BioMed Research International, Volume 2026, Issue 1, 2026.
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder that significantly increases cardiovascular disease (CVD) risk in women. While insulin resistance and dyslipidemia are established contributors, growing evidence highlights mitochondrial dysfunction and chronic low‐grade inflammation as central drivers of cardiovascular ...
Olabimpe Caroline Badejogbin, Mary Olaoluwa Agunloye, Ojichukwuka Ebere Chijioke-Agu, Makinde Vincent Olubiyi, Success Oluwanifesimi Olugbuyiro, Olaniyi Azeez Soetan, Opeyemi Abel Bamgbose, Tobi Opeyemi Olaleye, Swaran J. S. Flora   +8 more
wiley   +1 more source

Endothelin-1 Stimulates the Growth of Visceral and Subcutaneous Human Preadipocytes through Similar and Alternative Signaling Pathways via Type A and Type B Endothelin Receptors: Potential Implications for Therapeutic Strategies for Obesity and Metabolic Disorders. [PDF]

Int J Med Sci
Siao AC, Kao YH, Kuo CC, Shyu HY, Kuo YC, Chiang WF, Wu KA, Shih LJ, Hsiao PJ.   +8 more
europepmc   +1 more source

Ultrastructural Analysis of the Saphenous Vein Endothelium in a Patient With Proinflammatory Comorbidities Undergoing Coronary Artery Bypass Grafting

Case Reports in Medicine, Volume 2026, Issue 1, 2026.
The saphenous vein (SV) remains one of the most widely used grafts in coronary artery bypass grafting (CABG), and the integrity of the endothelium—a complex structure susceptible to deleterious effects from proinflammatory comorbidities—is a critical factor for graft patency. A 75‐year‐old patient with hypertension, dyslipidemia, insulin‐dependent Type
Matheus Duarte Pimentel, Heraldo Guedis Lobo Filho, José Glauco Lobo Filho, Sreeja Dattachoudhury   +3 more
wiley   +1 more source

Echinacea purpurea ameliorates Bleomycin-induced pulmonary fibrosis in rats through modulating NADPH oxidase-4 and endothelin-1/connective tissue growth factor/matrix metalloproteinases signalling axis. [PDF]

Sci Rep
Salama AAA, Elgohary R, Elwahab SA, Mostafa RE.   +3 more
europepmc   +1 more source

The Use of Tranexamic Acid to Treat Melasma: A Systematic Review and Meta‐Analysis

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Introduction Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits bleeding due to its effects on plasminogen conversion, approved by the FDA to treat menorrhagia and prevent bleeding in hemophilia patients undergoing dental extraction.
Nabila Scabine Pessotti, Vinicius Tassoni Civile, Talita Andrade Brandao, Felipe Ribeiro, Gisele Viana de Oliveira, Nathalia Sernizon Guimarães, Denise Steiner, Mahlatse Kgokolo   +7 more
wiley   +1 more source

Increased circulating Endothelin-1 is a risk factor for ECMO use and mortality in neonates with congenital diaphragmatic hernia: a prospective observational study. [PDF]

Respir Res
Lemloh L, de Vadder A, Melaku T, Bo B, Patel N, Holdenrieder S, Mueller A, Kipfmueller F.   +7 more
europepmc   +1 more source