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Prediction of Japan Score and Society of Thoracic Surgeons Risk Scores for Patients Undergoing Cardiovascular Surgery by Serum Growth Differentiation Factor-15 and Endothelin-1 Levels. [PDF]

Cureus
Fukuda T, Kato T, Kanazawa Y, Hirai R, Ishizaka H, Tan H, Shibasaki I, Fukuda H, Toyoda S, Nakajima T.   +9 more
europepmc   +1 more source

The dual endothelin-1 antagonist aprocitentan alleviates mitochondrial oxidative stress in human cardiac fibroblasts. [PDF]

Eur Heart J Cardiovasc Pharmacother
Varzideh F, Jankauskas SS, Jain U, Soderquist L, Densu Agyapong E, Kansakar U, Santulli G.   +6 more
europepmc   +1 more source

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Activation mechanism of endothelin ETB receptor by endothelin-1

Nature, 2016
Endothelin, a 21-amino-acid peptide, participates in various physiological processes, such as regulation of vascular tone, humoral homeostasis, neural crest cell development and neurotransmission. Endothelin and its G-protein-coupled receptor are involved in the development of various diseases, such as pulmonary arterial hypertension, and thus are ...
Wataru Shihoya, Tomohiro Nishizawa, Kazutoshi Tani   +2 more
exaly   +3 more sources

Endothelin-1 and Endotoxemia

Journal of Cardiovascular Pharmacology, 1993
Sepsis leads to changes in blood volume and distribution. In the experiments reported here we monitored circulatory changes during endotoxemia and their relation to portal and systemic levels of endothelin-1 (ET-1). Piglets were monitored cardiovascularly under ketamine anesthesia for 6 h after an endotoxin infusion (saline controls).
U, Myhre, J T, Pettersen, C, Risøe, K E, Giercksky   +3 more
openaire   +2 more sources

Endothelin-1-induced nociception

Life Sciences, 1991
Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection of endothelin-1 (ET-1; 0.1 mg/kg). The ED50 values (95% confidence intervals) were 39.3 (16.5-80.2) ng and 1.5 (0.8-4.9) ng, respectively.
R B, Raffa, J J, Schupsky, R P, Martinez, H I, Jacoby   +3 more
openaire   +2 more sources

Endothelin-1, endothelin converting enzyme-1 and endothelin receptors in the porcine corpus luteum

Domestic Animal Endocrinology, 2010
Porcine corpora lutea (CL) fail to show a luteolytic response to prostaglandin-F-2alpha (PGF-2alpha) (ie, luteolytic sensitivity [LS]) until about day 12-13 of the estrous cycle. Although little is known of the control of LS in any species, endothelin-1 (EDN1) is believed to play a role in LS control in ruminants.
L M, Zorrilla, R, Sriperumbudur, J E, Gadsby   +2 more
openaire   +2 more sources

Endothelin-1 and Endothelin-3 Stimulate Ovarian Steroidogenesis

Journal of Cardiovascular Pharmacology, 1991
The possible direct involvement of endothelin (ET) in preovulatory follicular steroidogenesis was investigated in vitro. Follicular development in immature rats was induced by pregnant mare's serum gonadotropin (PMS). Twenty-four and 48 h after PMS injection, ovarian follicles were incubated in vitro with or without 4 x 10(-11) to 4 x 10(-5) M ...
S, Usuki, T, Saitoh, N, Suzuki, C, Kitada, K, Goto, T, Masaki   +5 more
openaire   +2 more sources