Results 321 to 330 of about 141,025 (360)
Some of the next articles are maybe not open access.
Neuroscience, 1999
Neurons likely to use endothelin as a neurotransmitter/neurohormone were mapped in the rat brain using polyclonal antibodies directed against endothelin-converting enzyme-1, endothelin-1, and endothelin-3. Anti-endothelin-converting enzyme-1 antibodies produced the most robust staining, permitting the best visualization of the distribution and ...
J M, Sluck +4 more
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Neurons likely to use endothelin as a neurotransmitter/neurohormone were mapped in the rat brain using polyclonal antibodies directed against endothelin-converting enzyme-1, endothelin-1, and endothelin-3. Anti-endothelin-converting enzyme-1 antibodies produced the most robust staining, permitting the best visualization of the distribution and ...
J M, Sluck +4 more
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Endothelin receptors and endothelin-1 in developing rat teeth
Archives of Oral Biology, 2007The endothelins are a family of small peptides with multiple roles in a variety of tissues. Signaling is mediated through two receptor subtypes, the endothelin A receptor (ET(A)) specific for Et-1 and the non-specific endothelin B receptor (ET(B)).Our goal was to determine the location of immunoreactivity (IR) for ET(A) and ET(B) in developing and ...
Scott J, Neuhaus, Margaret R, Byers
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Endothelin-1 and endothelin-3 binding to rat nephrons
American Journal of Physiology-Renal Physiology, 1993The existence of endothelin (ET) receptor subtypes has recently been implicated in the different biological effects of ET in various tissues. Indeed, the cDNAs for two types of ET receptors, ETA and ETB, have been cloned. To further gain insights into ET function in the kidney we examined 125I-labeled ET-1 and ET-3 binding to microdissected rat ...
F, Takemoto +3 more
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Endothelin-1 and tumour development
European Journal of Surgical Oncology (EJSO), 1998There has been a growing conviction amongst oncologists that cancer is a disease characterized by changes in specific molecules. These changes include alteration in the structure, regulation or quantity of growth factors and their receptors, signal transducers and the proteins encoded by dominant or suppressor/recessive oncogenes.
E H, Asham, M, Loizidou, I, Taylor
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Nociceptive sensitization by endothelin-1
Brain Research Reviews, 2009The endogenous peptide endothelin-1 (ET-1), originally identified as a potent vasoconstrictor, plays a role in a number of painful conditions. In this review article we discuss the mechanisms that are essential for local sensitization by subcutaneously administered ET-1, and report evidence of ET-1's ability to sensitize distant regions of the body ...
Hans, Guy +2 more
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Endothelin-1 and myocardial preconditioning
American Heart Journal, 1996This study attempted to define the role of endothelin (ET) in preconditioning. We previously showed that ET Is produced during myocardial ischemia and reperfusion. Because both preconditioning and ET act through protein kinase C, ET could play a role in preconditioning.
J M, Erikson, C E, Velasco
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The Journal of clinical endocrinology and metabolism, 1997
We have previously reported the presence of endothelin-1 (ET-1) and its receptors in the human testis. In the present study we extended our investigations to human epididymis. The rationale of our study originated from the fact that sperm appear to be immotile during their transit through the epididymis.
PERI, ALESSANDRO +10 more
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We have previously reported the presence of endothelin-1 (ET-1) and its receptors in the human testis. In the present study we extended our investigations to human epididymis. The rationale of our study originated from the fact that sperm appear to be immotile during their transit through the epididymis.
PERI, ALESSANDRO +10 more
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Fluorescence studies of endothelin-1
Neurochemistry International, 1991Fluorescence measurements and singlet singlet energy transfer experiments on endothelin-1 provide information on the conformation of this peptide in dilute aqueous solution. The tyrosine fluorescence quantum yield in the absence of transfer (in [Phe(21)]endothelin-1) is relatively large (?(tyr) = 0.39), indicating the side-chain is oriented away from ...
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