Results 31 to 40 of about 23,650,103 (189)
Mitochondrial Fission Inhibitors Suppress Endothelin-1-Induced Artery Constriction
Cellular Physiology and Biochemistry, 2017 Background/Aims: Endothelin-1 is implicated in the pathogenesis of hypertension, but the underlying mechanisms remained elusive. Our previous study found that inhibition of mitochondrial fission of smooth muscle cells suppressed phenylephrine- and high K+
Chang Chen +11 more
doaj +1 more source
Endothelium-derived endothelin-1 [PDF]
Pflügers Archiv - European Journal of Physiology, 2009 One year after the revelation by Dr. Furchgott in 1980 that the endothelium was obligatory for acetylcholine to relax isolated arteries, it was clearly shown that the endothelium could also promote contraction. In 1988, Dr. Yanagisawa's group identified endothelin-1 (ET-1) as the first endothelium-derived contracting factor.
David J. Webb, Eric Thorin, Eric Thorin
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Role of endothelin-1 in periodontal diseases: A structured review
Indian Journal of Dental Research, 2016 Background and Objective: Endothelin-1 (ET-1) is a 21-amino acid peptide and is a potent vasoconstrictor produced by endothelial cells. It plays a role in the development of diseases such as hypertension and atherosclerosis.
Waleed Khalid +4 more
semanticscholar +1 more source
Expression of endothelin-1 and endothelin-1 receptor A in canine mammary tumours
Research in Veterinary Science, 2015 Endothelins and their receptors have been implicated in numerous diseases and have recently emerged as relevant players in a variety of malignancies. Tumours overexpress the Endothelin-1 (ET-1) and the Endothelin-A receptors (ETAR) and their interaction enhances tumour growth and metastasis by promoting tumour cell survival, proliferation and ...
RESTUCCI, BRUNELLA +2 more
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Endothelin‐1 and Endothelin Receptor Antagonists in Cardiovascular Remodeling
Proceedings of the Society for Experimental Biology and Medicine, 1999 Endothelins build a peptide family composed of three isoforms, each of them containing 21 amino acids. Endothelin‐1 is the isoform mainly responsible for any cardiovascular action and therefore the sole scope of this review. Endothelin‐1 is the most potent endogenous vasoconstrictor known; in addition it acts as a potent (co)mitogen.
Klaus Münter, Michael Kirchengast
openaire +3 more sources
Cells, 2019 Cost- and time-intensive porcine translational disease models offer great opportunities to test drugs and therapies for pathological cardiac hypertrophy and can be supported by porcine cell culture models that provide further insights into basic disease ...
Katrin Zlabinger +8 more
doaj +1 more source
JAMA cardiology, 2016 IMPORTANCE Despite pathophysiological links between endothelin-1 and pulmonary vascular remodeling, to our knowledge, the association between plasma endothelin-1 levels and pulmonary hypertension has not been studied in the general population.
M. Jankowich +2 more
semanticscholar +1 more source
Differentiation of endothelin-1 and endothelin-3 concentrations [PDF]
Gastroenterology, 1993 Inhaltsverzeichnis fehlt.
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Endothelin-1 in stable bronchiectasis [PDF]
European Respiratory Journal, 2000 Endothelin (ET)-1 has been suggested to promote neutrophil adhesion to endothelium, migration to inflamed areas, and release of elastase. ET-1 might therefore play a role in the pathogenesis of bronchiectasis, a chronic inflammatory and infective airway disease which is still poorly understood.
Ho, JCM +7 more
openaire +5 more sources
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
New England Journal of Medicine, 1993 BACKGROUND Pulmonary hypertension is characterized by an increase in vascular tone or an abnormal proliferation of muscle cells in the walls of small pulmonary arteries.
A. Giaid +9 more
semanticscholar +1 more source