Results 31 to 40 of about 141,025 (360)

Responses to neither exogenous nor endogenous endothelin-1 are altered in patients with hypercholesterolemia

Journal of Lipid Research, 2005
There is some controversy regarding whether vascular responses to endothelin are altered in hypercholesterolemia. Studies performed to date have been compromised by the use of endothelin antagonists at inappropriate concentrations.
Lauren M. Boak, Anthony M. Dart, Stephen J. Duffy, Jaye P.F. Chin-Dusting   +3 more
doaj   +1 more source

The role of endothelin-1 in pulmonary arterial hypertension. [PDF]

, 2014
Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
Chester, AH, Yacoub, MH
core   +1 more source

MiR-21, MiR-29a, GATA4, and MEF2c Expression Changes in Endothelin-1 and Angiotensin II Cardiac Hypertrophy Stimulated Isl-1⁺Sca-1⁺c-kit⁺ Porcine Cardiac Progenitor Cells In Vitro

Cells, 2019
Cost- and time-intensive porcine translational disease models offer great opportunities to test drugs and therapies for pathological cardiac hypertrophy and can be supported by porcine cell culture models that provide further insights into basic disease ...
Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Alfred Gugerell, Dominika Lukovic, Johannes Winkler, Julia Mester-Tonczar, Bruno Podesser, Mariann Gyöngyösi   +8 more
doaj   +1 more source

Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. [PDF]

PLoS ONE, 2018
To characterize the relationship between endothelin-1 and fibrosis in epiretinal membranes in proliferative diabetic retinopathy and explore the role of endothelial-mesenchymal transition in these membranes.Membranes were obtained from eyes undergoing ...
William Chang, Michelle Lajko, Amani A Fawzi   +2 more
doaj   +1 more source

Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes [PDF]

, 2008
Background: Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividing cells or hypertrophy in terminally differentiated cardiomyocytes.
Alsafi, A., Clerk, Angela, Cullingford, Timothy E., Dennis, Jayne L., Ekere, C., Fuller, Stephen John, Game, Laurence, Giraldo, Alejandro, Kemp, Timothy J., Markou, T., Pikkarainern, Sampsa, Sugden, Peter H., Zoumpoulidou, Georgia   +12 more
core   +2 more sources

Endothelin‐1 gene regulation

The FASEB Journal, 2010
Over two decades of research have demonstrated that the peptide hormone endothelin‐1 (ET‐1) plays multiple, complex roles in cardiovascular, neural, pulmonary, reproductive, and renal physiology. Differential and tissue‐specific production of ET‐1 must be tightly regulated in order to preserve these biologically diverse actions ...
Lisa R, Stow, Mollie E, Jacobs, Charles S, Wingo, Brian D, Cain   +3 more
openaire   +3 more sources

Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery [PDF]

, 2004
The influence of alloxan-induced diabetes on the reactivity of rabbit basilar artery to endothelin-1 was examined. Endothelin-1 induced concentration-dependent contraction of basilar arteries that was higher in diabetic than in control rabbits ...
Alabadí Ferrer, José Antonio, Alborch Domínguez, Enrique, Centeno Guil, José M., González Marrachelli, Vannina Elena, Lloréns, Silvia, Miranda Alonso, Francisco Javier   +5 more
core   +2 more sources

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1–induced pruritus [PDF]

Journal of Clinical Investigation, 2014
In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein-coupled receptor endothelin A receptor (ETAR).
Kido-Nakahara, Makiko, Buddenkotte, Jörg, Kempkes, Cordula, Ikoma, Akihiko, Cevikbas, Ferda, Akiyama, Tasuku, Nunes, Frank, Seeliger, Stephan, Hasdemir, Burcu, Mess, Christian, Buhl, Timo, Sulk, Mathias, Müller, Frank-Ulrich, Metze, Dieter, Bunnett, Nigel W, Bhargava, Aditi, Carstens, Earl, Furue, Masutaka, Steinhoff, Martin   +18 more
openaire   +4 more sources

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor [PDF]

, 2008
Background: Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods: We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35 ...
A Bagnato, A Bagnato, AV Budanov, D Salani, ER Levin, F Spinella, G Egidy, G Pan, H Peeters, H Walczak, HT Adler, J Eberle, J Nelson, JB Nelson, JD Stiles, Jennifer P Montgomery, JP Sheridan, JR Wu-Wong, K Ishikawa, K Kikuchi, K Takahashi, L Rosano, L Rosano, M Matsumoto, M Nagane, M Sone, M Takekawa, MC Hollander, N Kitagawa, Paul H Patterson, Q Zhan, Q Zhan, R Lahav, R Lahav, S He, S Jin, S Jin, S Velasco-Miguel, SP Harland, U Pagotto, V Naidoo, XW Wang, Y Berger   +42 more
core   +3 more sources

Identification of endothelin-1, endothelin-2 and endothelin-3 in human endometrium [PDF]

Reproduction, 1993
This study determined the presence of specific endothelin isoforms in human endometrium using high performance liquid chromatography (HPLC) combined with radioimmunoassay, and immunocytochemistry to detect the endothelin precursors (proendothelin-1, proendothelin-2 and proendothelin-3).
I T, Cameron, C, Plumpton, R, Champeney, C, van Papendorp, M J, Ashby, A P, Davenport   +5 more
openaire   +2 more sources