Results 41 to 50 of about 23,650,103 (189)
Endothelin in health and disease
Biomolecules & Biomedicine, 2004 Endothelin is a recently discovered peptide composed of 21 amino acids. There are three endothelin isomers: endothelin -1 (ET-1), endothelin -2 (ET-2) and endothelin - 3 (ET-3).
Emina Nakaš-Ićindić +3 more
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Brazilian Journal of Medical and Biological Research, 2005 Increased pulmonary vascular resistance in preterm newborn infants with respiratory distress syndrome is suggested, and endothelin-1 plays an important role in pulmonary vascular reactivity in newborns.
A.C.W. Benjamin +2 more
doaj +1 more source
Endothelin-1 contributes to the development of virus-induced demyelinating disease
Journal of Neuroinflammation, 2020 Background Experimental autoimmune encephalitis (EAE) and virally induced demyelinating disease are two major experimental model systems used to study human multiple sclerosis.
Young-Hee Jin +4 more
doaj +1 more source
Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat. [PDF]
PLoS ONE, 2017 BACKGROUND:Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role.
Gry Freja Skovsted +5 more
doaj +1 more source
Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation
Mediators of Inflammation, 1994 The possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited
Hajime Inoue +7 more
doaj +1 more source
Proteostasis Response to Protein Misfolding in Controlled Hypertension
Cells, 2022 Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira +12 more
doaj +1 more source
پزشکی بالینی ابن سینا, 2021 Background and Objective: Due to the significant importance of the teeth in mastication, speech, and aesthetics, it is necessary to identify all involved genes in the tooth development. Therefore, this study aimed to evaluate the role of endothelin-1 and
Soussan Irani +2 more
doaj
The Role of Endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis
Archivum Immunologiae et Therapiae Experimentalis, 2014 Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB.
A. Kowalczyk +4 more
semanticscholar +1 more source
The role of endothelin-1 in pulmonary arterial hypertension
Global Cardiology Science & Practice, 2014 Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
A. Chester, M. Yacoub
semanticscholar +1 more source
Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis.
Journal of the American Society of Nephrology, 2014 The endothelin system has emerged as a novel target for the treatment of diabetic nephropathy. Endothelin-1 promotes mesangial cell proliferation and sclerosis.
O. Lenoir +10 more
semanticscholar +1 more source