Results 51 to 60 of about 23,650,103 (189)
Chinese Journal of Lung Cancer, 2008 Background and objective Endothelin-1 (ET-1) is a potent mitogen involved in cell growth in human lung adenocarcinoma cells SPC-A1. The increase in intracellular free calcium ([Ca2+]i) plays a great role in this process.
Juan ZHOU +3 more
doaj
Pulmonary Circulation, 2020 Enhanced vasoconstriction is increasingly identified as an important contributor to the development of pulmonary hypertension. Chronic hypoxia results in enhanced Rho kinase mediated Ca 2+ sensitization contributing to pressure-dependent pulmonary ...
Charles E Norton +3 more
doaj +1 more source
Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.
Journal of Clinical Investigation, 2014 In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein-coupled receptor endothelin A ...
M. Kido-Nakahara +18 more
semanticscholar +1 more source
Endocrine and Metabolic Science, 2023 Introduction: African Americans (AAs) have the highest prevalence of hypertension among United States racial/ethnic groups. Regulators of blood pressure, such as aldosterone and endothelin-1, impact glucose regulation.
Joshua J. Joseph +7 more
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Evidence for G‐Protein–Coupled Estrogen Receptor as a Pronatriuretic Factor
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background The novel estrogen receptor, G‐protein–coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt‐induced complications, yet there is no ...
Eman Y. Gohar +11 more
doaj +1 more source
Egyptian Journal of Chest Disease and Tuberculosis, 2012 Study objective: This study analyses for the first time endothelin-1 (ET-1) level, and gene polymorphisms for endothelin-1 (EDN1 gene) in patients with pulmonary arterial hypertension (PAH) in Egypt. Design: Cross-sectional study.
Emad Ibrahim +2 more
doaj +1 more source
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2014 Background Despite the accumulating genetic and molecular investigations into hypertrophic cardiomyopathy (HCM), it remains unclear how this condition develops and worsens pathologically and clinically in terms of the genetic–environmental interactions ...
Atsushi Tanaka +18 more
semanticscholar +1 more source
Correlation between plasma endothelin-1 levels and severity of septic liver failure quantified by maximal liver function capacity (LiMAx test). A prospective study. [PDF]
PLoS ONE, 2017 To investigate the relationship between the degree of liver dysfunction, quantified by maximal liver function capacity (LiMAx test) and endothelin-1, TNF-α and IL-6 in septic surgical patients.28 septic patients (8 female, 20 male, age range 35-80y) were
Magnus F Kaffarnik +6 more
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Journal of Pharmacological Sciences, 2003 We examined the effect of endothelin-1, endothelin-3 and sarafotoxin S6c on the release of noradrenaline from gastric sympathetic nerve terminals using an isolated, vascularly perfused rat stomach.
Kumiko Nakamura +2 more
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ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes. [PDF]
PLoS ONE, 2010 Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g.
Andrew K Marshall +5 more
doaj +1 more source