Endothelin Receptor Antagonists in Kidney Disease. [PDF]
Int J Mol Sci, 2023 Endothelin (ET) is found to be increased in kidney disease secondary to hyperglycaemia, hypertension, acidosis, and the presence of insulin or proinflammatory cytokines.
Martínez-Díaz I +7 more
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Pulmonary Circulation, 2020 Adherence to therapy for pulmonary arterial hypertension is essential to optimize patient outcomes, but data on real-world adherence to different pulmonary arterial hypertension drug classes are limited.
Robert P. Frantz +6 more
doaj +2 more sources
Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin [PDF]
Clinical, Cosmetic and Investigational Dermatology, 2023 Carolina Nunhez da Silva,1 Hélio Amante Miot,1 Tony Fernando Grassi,2 Luciane Alarcão Dias-Melício,2– 4 Leandro Santos,2,3 Ana Cláudia Cavalcante Espósito1 1Department of Dermatology, São Paulo State University (UNESP) - Medical School of Botucatu ...
da Silva CN +5 more
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Stretching Promotes Wound Contraction Through Enhanced Expression of Endothelin Receptor B and TRPC3 in Fibroblasts [PDF]
Plastic and Reconstructive Surgery, Global Open, 2023 Background:. One factor that can contribute to the development of hypertrophic scar contracture is mechanical stress. Mechanical cyclic stretch stimuli enhance the secretion of endothelin-1 (ET-1) from keratinocyte.
Kenichiro Kawai, MD, PhD +6 more
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Artery Research, 2009 Background. Experimental cerebral ischemia and organ culture of cerebral arteries result in enhanced expression of endothelin ETB receptors in smooth muscle cells. The present study was designed to evaluate the involvement of calcium-calmodulin dependent
R. Waldsee +3 more
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Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going
Biology, 2022 Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two converting enzymes were identified, and their basic functions were elucidated by numerous ...
Andreas Haryono +3 more
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Endothelin receptor antagonists in diabetic and non-diabetic chronic kidney disease. [PDF]
Clin Kidney JIvković V, Bruchfeld A.
europepmc +3 more sources
Genetic interactions between neurofibromin and endothelin receptor B in mice. [PDF]
PLoS ONE, 2013 When mutations in two different genes produce the same mutant phenotype, it suggests that the encoded proteins either interact with each other, or act in parallel to fulfill a similar purpose.
Mugdha Deo +2 more
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Endothelin Receptor Antagonists: Status Quo and Future Perspectives for Targeted Therapy
Journal of Clinical Medicine, 2020 The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin receptor antagonists (ERAs), such as bosentan, ambrisentan, or macitentan,
Frederik C Enevoldsen +5 more
semanticscholar +1 more source
Endothelin B Receptors on Primary Chicken Müller Cells and the Human MIO-M1 Müller Cell Line Activate ERK Signaling via Transactivation of Epidermal Growth Factor Receptors. [PDF]
PLoS ONE, 2016 Injury to the eye or retina triggers Müller cells, the major glia cell of the retina, to dedifferentiate and proliferate. In some species they attain retinal progenitor properties and have the capacity to generate new neurons. The epidermal growth factor
Mohammad Harun-Or-Rashid +3 more
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