Results 121 to 130 of about 2,334,067 (354)

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye, Claire Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al‐Hosni, Paolo Tammaro   +5 more
wiley   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Current Status of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension: A Combined Study Results and Pharmacology-Based Review. [PDF]

Cureus, 2023
Nahar S, Kanda S, Chatha U, Odoma VA, Pitliya A, AlEdani EM, Bhangu JK, Javed K, Manshahia PK, Yu AK.   +9 more
europepmc   +1 more source

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease—A practical update for clinicians

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink, Dominique van Mil, Gozewijn D. Laverman, Hiddo J. L. Heerspink, Ron T. Gansevoort   +4 more
wiley   +1 more source

Clinicians' preferences for managing aneurysmal subarachnoid hemorrhage using endothelin receptor antagonists. [PDF]

Front Neurol, 2023
Heidenreich S, Trapali M, Krucien N, Phillips-Beyer A.   +3 more
europepmc   +1 more source

BQ123, an ETA Receptor Antagonist, Attenuates Endothelin-1-Induced Vasoconstriction in Rat Pulmonary Circulation

, 1993
S. T. Bonvallet, Masahiko Oka, M. Yano, Martin R. Zamora, Ivan F. McMurtry, Thomas J. Stelzner   +5 more
openalex   +1 more source

Pathophysiological Roles of Endothelin Receptors in Cardiovascular Diseases

Journal of Pharmacological Sciences, 2012
Endothelin (ET)-1 derived from endothelial cells has a much more important role in cardiovascular system regulation than the ET-2 and ET-3 isoforms. Numerous lines of evidence indicate that ET-1 possesses a number of biological activities leading to ...
Mamoru Ohkita, Masashi Tawa, Kento Kitada, Yasuo Matsumura   +3 more
doaj  

Effects of combined treatment with zibotentan and dapagliflozin compared to dapagliflozin alone in patients with diabetic and non‐diabetic chronic kidney disease

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate whether type 2 diabetes status modifies the efficacy and safety of combining zibotentan (zibo), a selective endothelin receptor antagonist, and dapagliflozin (dapa) compared to placebo plus dapagliflozin in individuals with chronic kidney disease (CKD).
Victor Wasehuus, J. David Smeijer, Phil Ambery, Peter J. Greasley, Emma Wijkmark, David C. Wheeler, Peter Rossing, Hiddo J. L. Heerspink   +7 more
wiley   +1 more source

Endothelin Receptor-A Inhibition Decreases Ductular Reaction, Liver Fibrosis, and Angiogenesis in a Model of Cholangitis. [PDF]

Cell Mol Gastroenterol Hepatol, 2023
Owen T, Carpino G, Chen L, Kundu D, Wills P, Ekser B, Onori P, Gaudio E, Alpini G, Francis H, Kennedy L.   +10 more
europepmc   +1 more source

Endothelin receptor subtypes in human and guinea‐pig pulmonary tissues [PDF]

, 1993
Douglas W.P. Hay, Mark A. Luttmann, Walter C. Hubbard, Bradley J. Undem   +3 more
openalex   +1 more source