Results 131 to 140 of about 2,334,067 (354)

The endothelin system in pulmonary and renal vasculopathy: les liaisons dangereuses

European Respiratory Review, 2009
Endothelial cells regulate vascular tone largely by the actions of endothelin-1. Endothelin-1 is a potent vasoconstrictor, with effects that are dependent on the receptors to which it binds as well as their location.
J-L Vachiéry, A. Davenport
doaj  

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

European Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano, Emmanuel Somm, François R. Jornayvaz, Nicolas Vuilleumier   +3 more
wiley   +1 more source

Ca2+ signal is involved in endothelin-1-induced internalization of endothelin type A receptor expressed in Chinese hamster ovary cells

Journal of Pharmacological Sciences, 2019
Endothelin type A receptor (ETAR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETAR expressed in Chinese hamster ovary ...
Takahiro Horinouchi, Sarita Karki, Koji Terada, Yuichi Mazaki, Soichi Miwa   +4 more
doaj  

Aselacins, novel compounds that inhibit binding of endothelin to its receptor. II. Isolation and elucidation of structures.

, 1994
Jill E. Hochlowski, PRESTON HILL, David N. Whittern, MICHAEL H. SCHERR, Ronald R. Rasmussen, Sarah A. Dorwin, James B. McAlpine   +6 more
openalex   +2 more sources

Evidence for a differential location of vasoconstrictor endothelin receptors in the vasculature [PDF]

, 1994
Suzanne Moreland, Diane M. McMullen, Benoni E. Abboa‐Offei, Andrea A. Seymour   +3 more
openalex   +1 more source

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches

PROTEOMICS, EarlyView.
Paul Perco, Matthias Ley, Kinga Kęska‐Izworska, Dorota Wojenska, Enrico Bono, Samuel M. Walter, Lucas Fillinger, Klaus Kratochwill   +7 more
wiley   +1 more source

WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution

The FEBS Journal, EarlyView.
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert, Ajaree Mongkolsittisilp, Andrei Kobitski, Matthias Schulz, Oksana Voloshanenko, Meike Schaffrinski, Nadine Winkler, Michelle Neßling, Karsten Richter, Dominique Kranz, Karin Nienhaus, Dirk Jäger, Lorenz Trümper, Judith Büntzel, Claudia Binder, Gerd Ulrich Nienhaus, Michael Boutros   +16 more
wiley   +1 more source

What is the impact of endothelin receptor blockade on atrial remodeling in a hypertensive model? [PDF]

Int J Cardiol Heart Vasc, 2022
Van Wagoner DR.
europepmc   +1 more source

Aselacins, novel compounds that inhibit binding of endothelin to its receptor. I. The producing organism, fermentation and biological activity.

, 1994
MARIANNA JACKSON, Neal S. Burres, James P. Karwowski, LISA A. ALDER, PATRICK E. HUMPHREY, William L. Kohl, JAMES B. Me ALPINE   +6 more
openalex   +2 more sources

Safety and tolerability of bosentan in the management of pulmonary arterial hypertension

Drug Design, Development and Therapy, 2009
Kari E Roberts, Ioana R PrestonPulmonary, Critical Care and Sleep Medicine, Tufts Medical Center, Boston, Massachusetts, USAAbstract: Endothelin receptor antagonism has emerged as an important therapeutic approach in pulmonary arterial hypertension (PAH).
Kari E Roberts, Ioana R Preston
doaj