ABSTRACT Background Hyperpigmentation disorders, including melasma and post‐inflammatory hyperpigmentation (PIH), are common dermatologic conditions associated with significant cosmetic and psychological burden. Tranexamic acid (TXA), an antifibrinolytic agent, has gained increasing attention due to its anti‐inflammatory and antimelanogenic properties.
Ahmed AlJabr +2 more
wiley +1 more source
In vivo optoacoustic imaging of endothelin receptor expression and treatment response in the hypoxic tumor microenvironment. [PDF]
Höltke C +7 more
europepmc +1 more source
Clinicians' preferences for managing aneurysmal subarachnoid hemorrhage using endothelin receptor antagonists. [PDF]
Heidenreich S +3 more
europepmc +1 more source
Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati +4 more
wiley +1 more source
The role of endothelin receptor antagonists in kidney disease. [PDF]
Ma X +5 more
europepmc +1 more source
ENDOTHELIN TYPE B RECEPTOR COULD BE ASSOCIATED WITH A PRO-CATABOLIC AND PRO-HYPERTROPHIC PHENOTYPE IN CHONDROCYTES [PDF]
EL MAKHLOUFI Jaouhara +8 more
openalex +1 more source
Prevention of cold ischaemia-reperfusion injury by an endothelin receptor antagonist in experimental renal transplantation [PDF]
I. Herrero
openalex +1 more source
Current Challenges in Hemostasis and Advances in Particle‐Assisted Styptic Devices
Here persistent limitations in hemostatic technologies are highlighted and cutting‐edge biomimetic, microparticle‐assisted, and nanoengineered systems with integrated drug delivery are showcased. Moreover, the article identifies fresh directions toward the next‐generation of multifunctional hemostatic devices with superior efficacy and accessibility ...
Daniele Baiocco +4 more
wiley +1 more source
Endothelin Receptor Antagonists for the Treatment of Hypertension: Recent Data from Clinical Trials and Implementation Approach. [PDF]
Manickavasagar R +3 more
europepmc +1 more source

