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Update on Endothelin Receptor Antagonists in Hypertension
Current Hypertension Reports, 2018M. Burnier
semanticscholar +1 more source
1998
Since the original discovery of endothelin (ET) by Yanagisawa et al in 1988,1 the scientific interest in this area of research has grown exponentially. It was originally hypothesized that ET interacts with two subtypes of receptors to mediate its biological functions and subsequent cloning of two ET receptors confirmed the original hypothesis.
openaire +1 more source
Since the original discovery of endothelin (ET) by Yanagisawa et al in 1988,1 the scientific interest in this area of research has grown exponentially. It was originally hypothesized that ET interacts with two subtypes of receptors to mediate its biological functions and subsequent cloning of two ET receptors confirmed the original hypothesis.
openaire +1 more source
[Endothelin receptor antagonist].
Nihon rinsho. Japanese journal of clinical medicine, 2009Pulmonary arterial hypertension(PAH) is an uncommon disease characterised by a progressive increase in pulmonary vascular resistance. An imbalance between vasoconstrictor/vasodilator activities could be responsible for altered pulmonary vascular tone and structure. In PAH patients, endothelin are increased.
Takuya, Kishi, Kenji, Sunagawa
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X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Nature Structural &Molecular Biology, 2017W. Shihoya +11 more
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Current treatment and recent progress in gastric cancer
Ca-A Cancer Journal for Clinicians, 2021Smita S Joshi, Brian D Badgwell
exaly
Activation mechanism of endothelin ETB receptor by endothelin-1
Nature, 2016W. Shihoya +7 more
semanticscholar +1 more source
Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly