Results 81 to 90 of about 215,964 (304)

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

The relationship of endotoxaemia to peripheral and central nervous system inflammatory responses in Human African Trypanosomiasis [PDF]

, 2016
Endotoxaemia has been described in cases of Human African trypanosomiasis (HAT), but it is unclear if this phenomenon influences inflammatory pathology either in the periphery or central nervous system (CNS).
ELTAYB A. ABOUBAKER, Hurley, JEREMY M. STERNBERG, LORNA MACLEAN, Nyakundi, PETER G. E. KENNEDY   +5 more
core   +4 more sources

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Endotoxin exposure associated with respiratory health among European schoolchildren: The SINPHONIE study

Pulmonology
Background Evidence on the association between endotoxin exposure and respiratory health in children remains inconsistent, with limited research addressing school environments—key settings for daily exposure.
Ramen Munir Baloch, Donát Magyar, Peter Rudnai, Tamás Pándics, Zsuzsanna Remény-Nagy, Hanns Moshammer, Hanna Leppänen, Anne Hyvärinen, Martin Täubel, Dan Norbäck, Marta Gabriel, Sara Maio, Sandra Baldacci, Giuseppe Sarno, Giovanni Viegi, Eva Csobod, Eduardo de Oliveira Fernandes, Isabella Annesi-Maesano   +17 more
doaj   +1 more source

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

Cardiovascular Diabetology, 2009
Introduction Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by ...
Kumar Sudhesh, Sabico Shaun L, da Silva Nancy F, Al-Rubeaan Khalid, Al-Daghri Nasser M, Al-Attas Omar S, McTernan Philip G, Harte Alison L   +7 more
doaj   +1 more source

The effect of equine hyperimmune sera on TNF alpha activity in a L929 cell bioassay [PDF]

, 2006
In this pilot study we examined the effect of sera from a proprietary hyperimmune plasma product (Equiplas) on the activity of TNF: in an in vitro L929 cell bioassay. In brief, we report observations from 2 accessions of sera.
Johnson, M., Kotiw, M., Raghaven, C., Shiels, I. A., Wilson, R. P.   +4 more
core  

Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation [PDF]

, 2012
Background:: Tracheal aspirates (TAs) from critically ill neonates accumulate bacterial endotoxin and demonstrate mobilization of endotoxin-binding proteins, but the potential bioactivity of endotoxin in TAs is unknown.
Levy, Ofer, Mancuso, Christy J., Martin, Camilia Rivera, Nathe, Katheryn, Palmer, Christine D., Parad, Richard Barry, Philbin, Victoria J., Phillips, Michele F., Stoler-Barak, Liat, Van Marter, Linda Joanne   +9 more
core   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Endotoxin Contamination in Nanomaterials Leads to the Misinterpretation of Immunosafety Results

Frontiers in Immunology, 2017
Given the presence of engineered nanomaterials in consumers’ products and their application in nanomedicine, nanosafety assessment is becoming increasingly important. In particular, immunosafety aspects are being actively investigated.
Yang Li, Mayumi Fujita, Diana Boraschi
doaj   +1 more source