Results 51 to 60 of about 175,351 (295)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Entrepreneurial universities in a world educational system [PDF]
International Economic Policy, 2016 This article analyzes modern development tendencies of university activities, it proved establishing of a global educational system, which shows increase of university education role, competition escalating and transformation of modern universities ...
Iryna Kalenyuk, Anastasiia Dyachenko
doaj
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Prospects of the endowment instrument in the financing system of the social sector in modern Russia
Вестник Северо-Кавказского федерального университетаIntroduction. In modern socio-economic conditions of Russia, it is necessary to stimulate additional and long-term financing instruments for the activities of non-profit organizations to solve socially significant problems.
S. V. Mitrofanova
doaj +1 more source
Développement Durable et Territoires, 2004 This article explores the relationship between poverty and sustainability. The study is based upon qualitative research conducted in CAR and a conceptual framework that emphasizes individuals' choice capabilities.
Benoît Lallau
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Community Development Foundations: Emerging Partnerships. [PDF]
, 2000 This report examines the emerging picture of local institutions that exist solely to support the civil society sector by building their operational and financial capacity.
Joyce Malombe
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Экономика: стратегия и практика, 2019 This article examines the foreign practice of public-private partnership in the higher education system, describes the importance of endowment funds as a mechanism of financing in higher education.
Z. Aubakirova +2 more
doaj
University reserves management: international practices and opportunities for Lithuania
Business, Management and Education, 2011 The article considers the new opportunities for university reserves management arising in the process of transition to non-profit institution model in Lithuania.
Gediminas Černiauskas, Jusif Seiranov
doaj +1 more source