Results 61 to 70 of about 175,351 (295)

New Financial Realities: The Response of Private Foundations [PDF]

open access: yes, 2009
Reviews the causes of the 2008 financial crisis and its impact on private foundations, proposes a framework for analyzing the sector, offers lessons learned on endowment management, and examines the implications for spending plans and program ...
John E. Craig, Jr.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Community Foundations: Growing Philanthropy Close to Home [PDF]

open access: yes, 2003
Describes the rapid growth and appeal of community foundations, including how they provide mechanisms for effective giving and have become local and regional facilitators.

core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Estimating the Willingness to Endow in the Capital Market with Emphasis on the Proposed Structure of the Waqf Investment Fund and Its Determinants [PDF]

open access: yesتحقیقات مالی اسلامی (پیوسته)
1. Introduction and ObjectiveThe institution of waqf (endowment) is one of the oldest and most influential mechanisms within Islamic economic thought, historically employed to reduce poverty, promote social welfare, and support cultural and educational ...
Saeed Farahanifard   +2 more
doaj   +1 more source

Community Foundation of the Mahoning Valley - 2004 Annual Report [PDF]

open access: yes, 2005
Contains mission statement, funds list, grants list, financial statement, and lists of board members, investment committee members, and ...

core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Entrepreneurial universities and formation features of self-learning organizations in the Russian economy

open access: yesПутеводитель предпринимателя, 2020
The article explores the cognitive and productive potential of entrepreneurial universities as the most advancedforms of self-learning organizations in the modern knowledge economy.
I. S. Salihova
doaj  

Homer Foundation - 2007 Annual Report [PDF]

open access: yes, 2007
Contains mission statement, director's message, program information, financial statements, reports from the distributions and investment committees, grants list, donor information, and list of board ...

core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

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