Results 201 to 210 of about 132,922 (266)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Concurrent inflammatory, hemorheological and macrovascular responses to a 230-km ultramarathon: an exploratory study. [PDF]

Sci Rep
Grau M, Bruns J, John L, Munk M, Siebers M, Bloch W, Bizjak DA.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Glucose dynamics during ultramarathon running: a multi-phase framework and implications for late-stage glucose elevations. [PDF]

Front Sports Act Living
Ishihara K, Kosaka H, Taniguchi H, Kakizaki H.   +3 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Evolved increases in running performance in cold hypoxia in high-altitude deer mice. [PDF]

J Exp Biol
Somo DA, Marangozis SC, Cumming MLL, McClelland GB, Scott GR.   +4 more
europepmc   +1 more source

Acute Clinical Effects of Dual-Task Resistance Exercise on Muscle Endurance and Pressure Sensitivity in Patients With Carpal Tunnel Syndrome After Surgery. [PDF]

Musculoskeletal Care
Núñez-Cortés R, Cruz-Montecinos C, López-Bueno L, López-Bueno R, Suso-Martí L, Salazar-Méndez J, Méndez-Rebolledo G, Morral A, Andersen LL, Calatayud J.   +9 more
europepmc   +1 more source

Impact of Moderate-Intensity Multicomponent Training on Cardiometabolic Health-Related Outcomes in Older Adults With Overweight and Obesity: A 9-Month Quasi-Experimental Single-Arm Pretest-Posttest Study. [PDF]

Australas J Ageing
Berbery E, de Salles Painelli V, Aizava PVS, de Souza Marques MG, Noronha ED, de Souza Marques DC, Oishi K, Hernandez-Martinez J, Valdés-Badilla P, Branco BHM.   +9 more
europepmc   +1 more source

Effects of eight weeks of eicosapentaenoic acid and medium-chain triacylglycerol structured lipid intake on EPA/AA ratio and muscle performance in young men. [PDF]

J Int Soc Sports Nutr
Shimizu T, Tsuchiya Y, Ueda H, Yokoi K, Yanagimoto K, Ochi E.   +5 more
europepmc   +1 more source

Physiological associations with heart rate-speed decoupling during a half-marathon in adolescent endurance runners. [PDF]

Front Physiol
Wang W, Zhou R, He G, Si Y, Cao Y, Zheng P, Zi W.   +6 more
europepmc   +1 more source