Results 41 to 50 of about 214,690 (314)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

The gut mucin-microbiota interactions: a missing key to optimizing endurance performance

Frontiers in Physiology, 2023
Endurance athletes offer unique physiology and metabolism compared to sedentary individuals. Athletes training at high intensities for prolonged periods are at risk for gastrointestinal disturbances.
Allison Clark, Núria Mach
doaj   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Prefrontal cortex oxygenation during endurance performance: A systematic review of functional near-infrared spectroscopy studies. [PDF]

, 2021
A myriad of factors underlie pacing-/exhaustion-decisions that are made during whole-body endurance performance. The prefrontal cortex (PFC) is a brain region that is crucial for decision-making, planning, and attention.
Habay, Jelle, Proost, Matthias, Díaz-García, Jesús, Roelands, B., Hurst, Philip, Meeusen, Romain, Van Cutsem, Jeroen, De Wachter, Jonas, Verstraelen, Matthias   +8 more
core   +1 more source

'Internal Splints' for Tetraplegics

South African Journal of Physiotherapy, 1985
The “Internal Splint for Tetraplegic Patients” concept is being used at the Spinal Units of the H.F, Verwoerd Hospital and Kalafong Hospital in Pretoria. It consists of: 1.
Ulrich Mennen
doaj   +1 more source

Enduring Contingency

Netherlands Journal of Legal Philosophy, 2023
Enduring Contingency: Remarks on the Precariousness of Liberal Democratic Law Van der Walt, in my reading, suggests that enduring contingency, in the twofold sense of an enduring state of contingency and of contingency as what needs to be endured, justifies the central role of the majority/minority principle in liberal democratic law.
openaire   +3 more sources

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study [PDF]

, 2010
Background: The aetiology and clinical significance of troponin release following endurance exercise is unclear but may be due to transient myocardial inflammation.
Wong Joyce, Whyte, G, Prasad, SK, Whyte, Greg, Smith Gillian, Annette Dahl, Smith, Gillian, Wage, R, Godfrey, R, Wilson, M, Gillian Smith, Francisco D Alpendurada, Sharma Sanjay, Prasad, Sanjay, O'Hanlon Rory, George Keith, Wage, Riccardo, Pennell, DJ, Pennell Dudley J, Roughton, Michael, Prasad Sanjay K, Roughton Michael, George, Keith, Rory O'Hanlon, Alpendurada Francisco D, Mat Wilson, Pennell, Dudley, Roughton, M, Sharma, S, Dahl, Annette, Greg Whyte, Sanjay K Prasad, Wilson Mat, Dave Oxborough, Alpendurada, Francisco, O'Hanlon, Rory, Keith George, Oxborough, Dave, Godfrey Richard, Wage Riccardo, Wong, Joyce, Dahl, A, Whyte Greg, Wilson, Mat, Smith, G, Joyce Wong, Richard Godfrey, Sanjay Sharma, Wong, J, Alpendurada, FD, Oxborough, D, Oxborough Dave, O'Hanlon, R, Dudley J Pennell, Riccardo Wage, Godfrey, Richard, Sharma, Sanjay, Michael Roughton, Dahl Annette, George, K   +59 more
core   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source