Results 21 to 30 of about 11,336,730 (199)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Influence of Multiscale Fillers Rein forcement into Impact Resistance and Energy Absorption Properties of Polyamide 6 and Polypropylene Nanocomposite Structures [PDF]
, 2013 Three-phase composites (thermoplastic polymer, glass-fibres and nano-particles) were investigated as an alternative to two-phase (polymer and glass-fibres) composites.
Sachse, Sophia +5 more
core +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Mechanical protection for composite structures submitted to low energy impact [PDF]
, 2010 Composite materials are widely used in aeronautical structures. These materials can be submitted to low energy impacts like tool drop, routine operations… Such impacts can generate damages in the material that significantly reduce the structure strength.
Bouvet, Christophe +4 more
core
Subsampling and homogenization to investigate variability of composite material mechanical properties [PDF]
, 2012 This paper presents an innovative homogenization sampling technique applied to multiscale modelling of composite materials. The goal is to build efficiently statistical variability of mechanical properties at mesoscopic scale from the heterogeneous media
DAU, Frédéric, PINEAU, Pierre
core +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Speed and Temperature Effects in the Energy Absorption of Axially Crushed Composite Tubes [PDF]
, 2008 Tubes of glass reinforced thermosetting resins have been tested in axial compression between steel platens with one end chamfered to prevent critically high loads causing catastrophic centre failure.
core +2 more sources
Advanced Engineering Materials, EarlyView.Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar +2 more
wiley +1 more source