Results 91 to 100 of about 3,937,771 (293)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Neural Network‐Based Multiple‐Model Adaptive Control of Grid‐Connected Inverters in Weak Grids

IET Power Electronics
Grid‐connected inverters (GCIs) operating in grid‐following (GFL) control may suffer from instability when connected to a weak grid characterised by a low short‐circuit ratio (SCR). Conversely, GCIs operating in grid‐forming (GFM) control may be unstable
Yu Xiao, Xing Zhang, Feng Han
doaj   +1 more source

Joint Wireless Information and Energy Transfer with Reduced Feedback in MIMO Interference Channels

, 2014
To determine the transmission strategy for joint wireless information and energy transfer (JWIET) in the MIMO interference channel (IFC), the information access point (IAP) and energy access point (EAP) require the channel state information (CSI) of ...
Clerckx, Bruno, Park, Jaehyun
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Energy access and sustainable development

AIP Conference Proceedings, 2015
With 1.4 billion people lacking electricity to light their homes and provide other basic services, or to conduct business, and all of humanity (and particularly the poor) are in need of a decarbonized energy system can close the energy access gap and protect the global climate system.
Kammen, Daniel M, Alstone, Peter, Gershenson, Dimitry   +2 more
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Darkening nights and rooftop solar adoption under South Africa’s electricity crisis: geographies of the energy apartheid

Environmental Research: Energy
Solar energy is the fastest-growing renewable electricity source globally. Under the guise of the green transition, solar energy is portrayed by energy optimists as sustainable despite its negative environmental and social externalities.
Zander S Venter, Shylet Chivanga, Megan Davies, Priscilla Monyai, Samantha L Scott   +4 more
doaj   +1 more source

Geospatial Planning for Least-Cost Electrification in Developing Countries

Energies
This paper presents two innovative procedures developed for rural electrification planning. To address the challenges of processing vast geospatial data, handling complex and computationally intensive network design, and making detailed yet accessible ...
Nicolò Ceccato, Corrado Maria Caminiti, Aleksandar Dimovski, Marina Petrelli, Midas Caubergs, Marco Merlo   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source