Results 121 to 130 of about 1,262,608 (310)

Progress in green hydrogen adoption in the African context

Frontiers in Energy Research
Hydrogen is an abundant element and a flexible energy carrier, offering substantial potential as an environmentally friendly energy source to tackle global energy issues. When used as a fuel, hydrogen generates only water vapor upon combustion or in fuel
Enoch I. Obanor, Joseph O. Dirisu, Oluwaseun O. Kilanko, Enesi Y. Salawu, Oluseyi O. Ajayi   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Energy End-Use Technologies for the 21st Century. A Report of the World Energy Council

, 2004
This report makes clear the opportunities and places technology development firmly centre stage in meeting and overcoming the challenges confronting the energy industry and policy makers.
Schock, R., Larsen, H., Gehl, S., Modlin, R., Morishita, M., Suntola, T., Nakicenovic, N., Haegermark, H.   +7 more
core  

Competing uses of biomass for energy and chemicals: Implications for long-term global CO2 mitigation potential

, 2015
Biomass is considered a low carbon source for various energy or chemical options. This paper assesses it’s different possible uses, the competition between these uses, and the implications for long-term global energy demand and energy system emissions. A
Faaij, André, Daioglou, Vasileios, Energy System Analysis, Wicke, Birka, Energy and Resources, van Vuuren, Detlef, Environmental Sciences   +6 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

World oil : availability and price the next ten years [PDF]

, 1986
"This report was prepared as a background paper for presentation and discussion at the Asian Development Bank's Regional Meeting on Energy Policy held on December 11-12, 1986 in Manila."--T.p.Includes bibliographical references.Research supported by the ...

core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Regulation of gene expression by photosynthetic signals triggered through modified CO2 availability

, 2006
Wormuth D, Baier M, Kandlbinder A, Scheibe R, Hartung W, Dietz K-J. Regulation of gene expression by photosynthetic signals triggered through modified CO2 availability. BMC PLANT BIOLOGY.
Scheibe Renate, Baier Margarete, Scheibe, Renate, Hartung, Wolfram, Dietz Karl-Josef, Karl-Josef Dietz, Wormuth, Dennis, Baier, Margarete, Margarete Baier, Dietz, Karl-Josef, Kandlbinder Andrea, Kandlbinder, Andrea, Renate Scheibe, Dennis Wormuth, Wormuth Dennis, Andrea Kandlbinder, Hartung Wolfram, Wolfram Hartung   +17 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source