Results 91 to 100 of about 358,220 (262)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Removal of the Energy Dependence from the Resolvent-like Energy-Dependent Interactions

open access: yes, 1995
The spectral problem $(A + V(z))ψ=zψ$ is considered with $A$, a self-adjoint Hamiltonian of sufficiently arbitrary nature. The perturbation $V(z)$ is assumed to depend on the energy $z$ as resolvent of another self-adjoint operator $A':$ $V(z)=-B(A'-z)^{-1}B^{*}$.
openaire   +2 more sources

Energy dependence of the 7Li + 16O interaction [PDF]

open access: yesЯдерна фізика та енергетика, 2006
Data of the 7 Li + 16O elastic and inelastic scattering at Ec.m. = 6.26 - 34.78 MeV were analyzed within the optical model (OM) and coupled-reaction-channels method.
A. A. Rudchik   +4 more
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Policy of Italy in regard to Arab states of Mediterranean sea

open access: yesHalyk̦aralyk̦ k̦atynastar ža̋ne halyk̦aralyk̦ k̦u̇k̦yk̦ seriâsì, 2017
This article examines the relationship between Italy and the Arab states. As a result of its central geographic position, acting as a natural bridge between Europe and Africa, Italy is undoubtedly more exposed and vulnerable than other countries to any ...
A. Б. Кузембаева   +1 more
doaj  

Neutron to proton ratio dependence of energy of vanishing flow: role of system size and collision geometry

open access: yesEPJ Web of Conferences, 2014
We study the effects of system size on the neutron to proton ratio dependence of the energy of vanishing flow for isotopic series of various colliding nuclei.
Gautam Sakshi
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Does oil dependence cause energy risk?

open access: yesEnergy Nexus
These days, the issue of energy risk is becoming more prevalent worldwide. Particularly, the issue of oil dependence raises awareness. The previous studies provide very limited background to this issue because of the absence of an energy risk variable ...
Bekhzod Kuziboev   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy