Results 161 to 170 of about 879,921 (312)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Hardware architecture for adaptive filtering based on energy-CFAR processor for radar target detection

open access: yes, 2010
A hardware architecture that implements an adaptive filter based on energy analysis of radar echoes to improve the detection of the Constant False Alarm Rate (CFAR) algorithm is presented. Signal processing based on energy analysis emphasizes the edge of
SANTOS MARTIN LOPEZ ESTRADA   +1 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Very high energy cosmic gamma rays from radio and x-ray pulsars [PDF]

open access: yes, 1987
This thesis is concerned with the detection of very high energy cosmic gamma-rays from isolated pulsars and X-ray binary sources using the atmospheric Cerenkov technique. A general introduction to gamma ray detection techniques is followed by adscription
Chadwick, P.M, Chadwick, Mary Paula
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

An efficient voice activity detection algorithm by combining statistical model and energy detection

open access: yesEURASIP Journal on Advances in Signal Processing, 2011
In this article, we present a new voice activity detection (VAD) algorithm that is based on statistical models and empirical rule-based energy detection algorithm. Specifically, it needs two steps to separate speech segments from background noise.
Wu Ji, Zhang Xiao-Lei
doaj  

Towards privacy-preserving anomaly-based intrusion detection in energy communities

open access: yes
Energy communities consist of decentralized energy production, storage, consumption, and distribution and are gaining traction in modern power systems. However, these communities may increase the vulnerability of the grid to cyber threats.
Giovanni Gaggero   +5 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

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