Results 31 to 40 of about 727,945 (265)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Energy Efficiency and Rebound Effect: Does Energy Efficiency Save Energy?

open access: yesEnergy and Power Engineering, 2011
The aim of this study is to examine the theoric and empirical literature about “rebound effect”. This study summarizes energy efficiency policy and programs in general and in Turkey. Also it gives defination of the “rebound effect” concept. The rebound effect is related to consumer’s tendency to consume more energy due to economic benefit from ...
Nurgün Topallı, Abdulkadir Bulu
openaire   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Energy saving and efficiency [PDF]

open access: yesEPJ Web of Conferences, 2020
Many products and package systems offered by manufacturers have been optimized under pressure from Europe’s eco-design regulations (e.g., Energy Related Products). This also gives the customer access to reliable product information at the time of purchase, which continuously encourages manufacturers to improve the energy efficiency of their products in
openaire   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Energy Efficient Homes: Incentive Programs for Energy Efficiency

open access: yesEDIS, 2008
FCS-3268, a 4-page fact sheet by Nicholas W. Taylor, M. Jennison Kipp, and Kathleen C. Ruppert, is part of the Energy Efficient Homes series. It defines key terms, tells who offers energy incentives, what types of incentives there are, and what considerations homeowners should have. Includes references.
Nicholas W. Taylor   +2 more
openaire   +3 more sources

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Energy Efficient Homes: Comparing Homes for Energy Efficiency

open access: yesEDIS, 2008
FCS-3272, a 7-page fact sheet by Nicholas W. Taylor, Jeffrey Michael, and Barbara Haldeman, provides Florida homebuyers with an overview for evaluating each home’s energy efficiency and a checklist to help evaluate and compare. Includes references. One of an Energy Efficient Homes series.
Nicholas W. Taylor   +2 more
openaire   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

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