Results 81 to 90 of about 19,595,599 (291)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Enhancement of energy efficiency and sustainability through green building index platinum certification in Malaysian building design

Majlesi Journal of Electrical Engineering
This paper presents a comprehensive study on enhancing energy efficiency (EE) and sustainability in building design, focusing on implementing the Green Building Index (GBI) Platinum standards for a proposed office development in Malaysia.
Billy Kee Haan Sia, Mohd Aifaa Mohd Ariff   +1 more
doaj   +1 more source

Report of the Energy Efficiency Board. 2010.

, 2010
Annual; Began with 2010.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Energy Efficiency Board 2018 programs and operations report.

, 2019
Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core   +1 more source

Analysis and Experimental Verification of Improving the EEDI of a Ship using a Thruster Supplied by a Hybrid Power System

Polish Maritime Research
In this study, the authors present a theoretical analysis and experimentally verified methods to improve the Energy Efficiency Design Index (EEDI) of ships.
Mindykowski Janusz, Wierzbicki Łukasz, Górniak Mariusz, Piłat Andrzej   +3 more
doaj   +1 more source

Report of the Energy Efficiency Board. 2012.

, 2013
Annual; Began with 2010.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core  

Capturing energy efficiency in European iron and steel production—comparing specific energy consumption and Malmquist productivity index

, 2014
European iron and steel producers are working towards increased energy efficiency to meet requirements set by European policies such as the Energy Efficiency Directive.
Johannes Morfeldt, Semida Silveira, Morfeldt, Johannes,, Silveira, Semida,   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Promotion of Efficient Use of Energy: Final Report

, 2006
The Department of Energy funded the Alliance to Save Energy to promote the efficient use of energy under a multiyear cooperative agreement. This funding allowed the Alliance to be innovative and flexible in its program development, and to initiate and ...
Alliance to Save Energy (U.S.)
core   +1 more source