Results 121 to 130 of about 8,290,976 (301)

Comprehensive measurement of energy market integration in East Asia: An application of dynamic principal component analysis

, 2015
The energy market integration (EMI) in East Asia has been carried out for over a decade. Despite the efforts exerted by countries in the region, little has been known about the EMI progress. This paper innovatively applies the dynamic principal component
Shi, Xunpeng, Zhang, D, Zhang, Dandan, Shi, X, Sheng, Y, Sheng, Yu   +5 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Sedimentary provenance supports a mid-paleozoic tectonic connection between the Junggar and Altai terranes in central Asia

Scientific Reports
The provenance of Precambrian detritus in the Junggar and Altai terranes provides crucial constraints on the peri-Siberian accretionary tectonic evolution in the middle Paleozoic.
Di Li, Yigui Han, Guochun Zhao, Mei-Fu Zhou, Dengfa He, Shuoqin Hou, Yu Zhen, Dan Fan, Hao Yang   +8 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Study on the mechanical traits, failure mechanisms, energy responses, and influencing factors of columnar jointed basalts under direct and indirect tensile conditions

Frontiers in Earth Science
In this study, by merging mesoscopic damage mechanics, the probabilistic strength principle, and continuum mechanics, the visuals of columnar jointed basalts (CJBs) featuring various joint arrangement patterns are converted into inhomogeneous numerical ...
Dan Liang, Dan Liang, Dan Liang, Haiqing Yang, Haiqing Yang, Zekang Ping, Zekang Ping, Yongyi Wang, Yongyi Wang, Kanglei Song, Kanglei Song, Chiwei Chen, Chiwei Chen, Hao Li, Hao Li, Xingyue Li, Xingyue Li, Lixin Peng, Lixin Peng, Anhua Ju, Anhua Ju   +20 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Energy evolution and key parameters of coal breaking by flexible cutting tools

Meitan xuebao
To solve the difficulties such as the small range of unloading pressure in hard coal seams and poor permeability enhancement effect, based on the water dynamic flexible cutting coal unloading and permeability enhancement technology, the combination of ...
Yong LIU, Zhikang ZHANG, Jianping WEI, Xiangyu XU, Yingjun GAO   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source