Results 51 to 60 of about 207,854 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Photosynthetic Temperature Tolerance Threshold Determines How Isoprene Emission is Affected by Elevated CO2 Concentration at High Temperatures

Plant-Environment Interactions
The suppression of isoprene emissions by high CO2 levels can be mitigated by increasing temperature; however, little is known about why and to what extent species differ in their temperature‐dependent release from high CO2 inhibition.
Vinícius Fernandes deSouza, José Francisco de Carvalho Gonçalves, Bakhtier Rasulov, Eero Talts, Catherine Morfopoulos, Sérgio Duvoisin Junior, Patrícia Melchionna Albuquerque, Ülo Niinemets   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Burning Trash for Science: The Potential Use of Discarded Waste to Monitor Energy Fluxes Delivered to Ecosystem Components by Wildfires

Fire
Assessing the energy flux delivered to ecosystem components by wildfires is hard because of technical and safety problems in performing measurements during such events.
Ania Losiak, Amber Avery, Andy Elliott, Sarah J. Baker, Claire M. Belcher   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Characterization of Submesoscale Turbulence in the East/Japan Sea Using Geostationary Ocean Color Satellite Images

Geophysical Research Letters, 2019
Submesoscale processes are key in understanding physical and biological phenomena near the surface, but there remains a lack of observational evidence over large areas.
J. Choi, Y.‐G. Park, W. Kim, Y. H. Kim
doaj   +1 more source

Fluctuations of Energy Flux in Wave Turbulence [PDF]

Physical Review Letters, 2008
We report that the power driving gravity and capillary wave turbulence in a statistically stationary regime displays fluctuations much stronger than its mean value. We show that its probability density function (PDF) has a most probable value close to zero and involves two asymmetric roughly exponential tails.
Falcon, Eric, Aumaître, Sébastien, Falcón, Claudio, Laroche, Claude, Fauve, Stéphan   +4 more
openaire   +4 more sources