Results 61 to 70 of about 207,854 (262)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Geography, Environment, Sustainability, 2019 Climate change has distinct regional and local differences in its impacts on the land sur face. One of the important parameters determining the climate change signal is the emissivity (ε) of the sur face.
Nina Tiralla +5 more
doaj +1 more source
Quasilocal energy flux of spacetime perturbation [PDF]
Physical Review D, 2008 A general expression for quasi-local energy flux for spacetime perturbation is derived from covariant Hamiltonian formulation using functional differentiability and symplectic structure invariance, which is independent of the choice of the canonical variables and the possible boundary terms one initially puts into the Lagrangian in the diffeomorphism ...
Tung, Roh-Suan, Yu, Hoi-Lai
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Energies of quantum QED flux tubes [PDF]
Journal of Physics A: Mathematical and General, 2006 9 pages latex, Talk presented at the QFEXT 05 workshop in Barcelona, Sept. 2005.
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Journal of AgrometeorologyThis study was carried out to understand the pattern of surface energy fluxes over a periodical scale and energy balance closure using Large Aperture Scintillometer and Micrometeorological tower.
ABHISHEK DANODIA +3 more
doaj +1 more source
Energy release and seismic flux
Annals of Geophysics, 1965 From the basic data and tlie previous results of priorpapers, we have made evaluations of the energy released and studied itsvariation. Its pulsative form is confirmed, which suggests several superposedperiods, perhaps of simple multiples of tlie ...
J. M. Munuera
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source