Results 91 to 100 of about 6,670,403 (347)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Modeling a Wave Energy Harvester for Supplying Data Buoys
Applied SciencesAn energy harvester scavenging the kinetic energy of fluctuating waves for supplying small sea monitoring buoys is studied and tested. The harvester exploits a magnetic cylinder that rolls on a track due to the pitching motion of the buoy.
Alessandro Lo Schiavo +2 more
doaj +1 more source
Piezoelectric energy harvesting from traffic-induced pavement vibrations [PDF]
, 2014 This paper focuses on the development and experimental testing of a potential clean energy source for powering the remote equipment used in transportation infrastructure.
Jiang, X, Li, J, Li, Y, Wang, J, Yao, J
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Models for 31-Mode PVDF Energy Harvester for Wearable Applications
The Scientific World Journal, 2014 Currently, wearable electronics are increasingly widely used, leading to an increasing need of portable power supply. As a clean and renewable power source, piezoelectric energy harvester can transfer mechanical energy into electric energy directly, and ...
Jingjing Zhao, Zheng You
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Piezoelectric Energy Harvesting from the Thorax Vibration of Freely Flying Bees
Cyborg and Bionic SystemsInsect cyborgs have been proposed for application in future rescue operations, environmental monitoring, and hazardous area surveys. An energy harvester for insect carrying is critical to the long-lasting life of insect cyborgs, and designing an energy ...
Zhiyun Ma +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Micromachines, 2020 Piezoelectric energy harvesting technology using the piezoelectric circular diaphragm (PCD) has drawn much attention because it has great application potential in replacing chemical batteries to power microelectronic devices.
Chaoqun Xu, Yuanbo Li, Tongqing Yang
doaj +1 more source
Energy harvesting using porous piezoelectric beam with impacts [PDF]
, 2017 An analytical model of impact energy harvester consisting of a cantilever beam with integrated piezoelectric patches and a ball is developed in this paper.
Adhikari, Sondipon +4 more
core +3 more sources