Results 71 to 80 of about 168,399 (308)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Harvesting energy from magnetic fields to power condition monitoring sensors

, 2013
Condition monitoring is playing an increasingly important role within electrical power networks, where its use can help to reduce maintenance costs, improve supply reliability and permit increased utilization of equipment capacity by providing a measure ...
Judd, Martin, Roscoe, Nina
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Comparison of energy-wood and pulpwood thinning systems in young birch stands [PDF]

, 2011
In early thinnings, a profitable alternative to pulpwood could be to harvest whole trees as energy-wood. In theoretical analyses, we compared the extractible volumes of energy-wood and pulpwood, and their respective gross values in differently aged ...
Kroon, Anders, Dan Bergström, Tomas Nordfjell, Fulvio Di Fulvio, Bergström, Dan, Anders Kroon, Nordfjell, Tomas, Di Fulvio, Fulvio   +7 more
core   +1 more source

Advancements in Single‐Atom Catalysts: Synthesis, Characterization, and Applications in Sensing Technologies

Small Science
Single‐atom catalysts (SACs) have rapidly progressed from early proof‐of‐concept studies to high‐performance sensing platforms. Their atomically dispersed active sites and tunable coordination environments, offer superior catalytic activity and ...
Ilakeya Subbiah Arivuthilagam, Raghisa Shahid, Md. Mahbubur Rahman, Jae‐Joon Lee   +3 more
doaj   +1 more source

Inertial Kinetic Energy Harvesters for Wearables: The Benefits of Energy Harvesting at the Foot

IEEE Access, 2020
Wearable devices promise to reduce strain on the healthcare system and to improve quality of life for users. However, adoption in healthcare settings is limited due in part to the need for constant battery maintenance; which leads to reduced adherence, more complex operation and missing sections of data.
Christopher Beach, Alexander J. Casson
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Novel Ferrocene-Linked Thionine as a Dual Redox Mediator for the Electrochemical Detection of Dopamine and Hydrogen Peroxide

Biosensors
We introduce a novel dual redox mediator synthesized by covalently linking ferrocene dicarboxylic acid (FcDA) and thionine (TH) onto a pre-treated glassy carbon electrode. This unique structure significantly enhances the electro-oxidation of dopamine (DA)
Manikandan Palinci Nagarajan, Manikandan Ramalingam, Ilakeya Subbiah Arivuthilagam, Vishwa Paramaguru, Md. Mahbubur Rahman, Jongdeok Park, Francis Kwaku Asiam, Byungjik Lee, Kwang Pyo Kim, Jae-Joon Lee   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

On the design of an energy-harvesting noise-sensing WSN mote [PDF]

, 2014
Wireless sensor networks (WSNs) could potentially help in the measurement and monitoring of noise levels, an important step in mitigating and fighting noise pollution.
Tan, Wilson M., Jarvis, Stephen A.; id_orcid, Wilson M Tan, Stephen A Jarvis, Jarvis, Stephen A.   +4 more
core   +1 more source