Results 51 to 60 of about 2,321,154 (310)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Digital Twin Technology and Energy Sustainability in China: A Regional and Spatial Perspective

Energies
This study aims to explore the role and impact of digital twin technology in enhancing the sustainable development of the energy industry so as to analyze how digital twin technology facilitates urban sustainability.
Yejin Liu, Min Ye
doaj   +1 more source

Smart distribution board overload detector by using microcontroller [PDF]

, 2020
A statistic by Economic Planning Unit (EPU) on the electricity growth in Malaysia has shown an increment in line with economic growth [1]. In line with government policies, the energy supply industry has been molding itself to cater to the rapid ...
Ismail, Muhammad Nafis, Kamarudin, Qamarul Ezani, Mohammad Azmi, Nurfiza Atikah, Mohd Jamail, Nor Akmal, Othman, Nordiana Azlin   +4 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Environmental, Social, and Governance (ESG) Dynamics in the Energy Sector: Strategic Approaches for Sustainable Development

Energies
ESG metrics have become increasingly important in evaluating corporate sustainability and meeting regulatory expectations. Thus, it is essential to explore these elements for a clearer understanding. This study examined the environmental (E), social (S),
Mustafa Yucel, Sevgi Yucel
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

CLASSIFICATION OF SYSTEMS FOR PASSIVE AFTERHEAT REMOVAL FROM REACTOR CONTAINMENT OF NUCLEAR POWER PLANT WITH WATER-COOLED POWER REACTOR

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2014
A classification on systems for passive afterheat removal from reactor containment has been developed in the paper.  The classification permits to make a detailed analysis of various concepts pertaining to systems for passive afterheat removal from ...
N. Khaled, D. V. Shevelev, A. S. Balashevsky   +2 more
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Desalination Processes’ Efficiency and Future Roadmap [PDF]

, 2019
For future sustainable seawater desalination, the importance of achieving better energy efficiency of the existing 19,500 commercial-scale desalination plants cannot be over emphasized.
Burhan, Muhammad, Ng, Kim, Shahzad, Muhammad Wakil, Ybyraiymkul, Doskhan   +3 more
core   +3 more sources