Results 61 to 70 of about 2,321,154 (310)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Vertical separation of the energy-distribution industry; an assessment of several options for unbundling [PDF]
The Dutch Minister of Economic Affairs has proposed to replace the currently implemented structure of legal unbundling of the energy distribution industry by ownership unbundling. In this study we analyse the costs and benefits of this proposal.
Machiel Mulder +2 more
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Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Politics of contemporary "Silk Roads"
Vestnik MGIMO-Universiteta, 2016 Recently in mass media we can find the idea about a new Silk Road or the concept of "Silk Road Economic Belt" which has been formulated by the Chinese PresidentXi Jinping on September 7,2013, during his official visit to Kazakhstan.
Andrey I. Litvinov
doaj +2 more sources
Energy Abundance, Trade and Industry Location [PDF]
We study the effect of countries’ energy abundance on trade and sector activity, conditional on sector’s energy intensity, using an unbalanced panel with 14 high-income countries from Europe, America and Asia, 10 broad sectors, and years 1970-1997.
Nicole A. Mathys, Reyer Gerlagh
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Wind Energy Resource Base and Incentives [PDF]
, 2006 Key facts: - At the beginning of 2006, the U.S. wind industry has a total generating capacity of 9,149 MW. - In 2005, the U.S. wind energy industry installing nearly 2,500 megawatts (MW) or over $3 billion worth of new generating equipment in 22 states ...
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SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Industrial Energy Efficiency: Using New Technologies to Reduce Energy Use in Industry and Manufacturing [PDF]
, 2006 Key facts: -Industry uses over one-third of the energy consumed in the United States.- Oil and natural gas provide nearly four-fifths of industrial energy; the rest comes mostly from electricity and coal. - Between 1990 and 2003, US industrial output has
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