Results 41 to 50 of about 227,764 (268)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Energy Management Control Strategy for Hybrid Energy Storage Systems in Electric Vehicles
International Journal of Electrochemical Science, 2022 This study describes an energy flow distribution control strategy based on a combined method for hybrid energy storage systems to achieve multiple control objectives.
Qiao Zhang, Xu Chen, Shaoyi Liao
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Smart energy strategies: Leveraging LSTM and LLMs for advanced energy management
Energy and AIAlmeida, F., Castelli, M., Côrte-Real, N., Fallarino, C., & Manzoni, L. (2025). Smart energy strategies: Leveraging LSTM and LLMs for advanced energy management. Energy and AI, 22, Article 100642. https://doi.org/10.1016/j.egyai.2025.100642 --- This work was supported by national funds through FCT (Fundação para a Ciência e a Tecnologia), under the ...
Almeida, Fernando +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
IEEE Open Journal of Vehicular Technology, 2020 Powertrain electrification has heightened the need for an energy management strategy, which has been a continuing concern in the development of electrified vehicles.
Reihaneh Ostadian +3 more
doaj +1 more source
Stateflow-Based Energy Management Strategy for Hybrid Energy System to Mitigate Load Shedding
Applied Sciences, 2021 This study investigates the potential application of Stateflow (SF) to design an energy management strategy (EMS) for a renewable-based hybrid energy system (HES).
Muhammad Paend Bakht +5 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Compound Energy Storage System and Energy Management Strategy for Electric Vehicles
Journal of Harbin University of Science and Technology, 2018 At present, the electric vehicles cannot be universal because of their short batteries life and driving range. An ultracapacitor and a DC/DC converter were added to the pure electric vehicles constituting the compound energy storage system.
ZHOU Mei-lan +2 more
doaj +1 more source
World Electric Vehicle Journal, 2023 Given the influence of the randomness of driving conditions on the energy management strategy of vehicles, deep reinforcement learning considering driving conditions prediction was proposed.
Jianguo Xi +3 more
doaj +1 more source