Results 41 to 50 of about 247,108 (269)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Optimization of Low-Carbon Technology Adoption Decision for Generation Enterprises Considering Cost Uncertainty

Zhongguo dianli
To investigate the investment decision optimization issue under the condition of uncertain cost of multiple types of low-carbon technologies faced by power generation enterprises to actively achieve the goal of "dual carbon", this paper takes the medium-
Qinliang TAN, Jiaming HE, Hanyu LV, Yihong DING   +3 more
doaj   +1 more source

Research on Energy Management Strategy of a Hybrid Commercial Vehicle Based on Deep Reinforcement Learning

World Electric Vehicle Journal, 2023
Given the influence of the randomness of driving conditions on the energy management strategy of vehicles, deep reinforcement learning considering driving conditions prediction was proposed.
Jianguo Xi, Jingwei Ma, Tianyou Wang, Jianping Gao   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

An attack-resilient distributed energy management strategy for integrated energy systems

Frontiers in Energy Research
The increasing integration of various energy sources and the adoption of smart grid technologies have revolutionized the way we generate, distribute, and consume energy.
Tong Li, Feng Sun, Jian Chen, Lei Wang, Zhibin Yang, Ruitong Liu, Jun Qi   +6 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Study on resilient energy management strategy for ship-integrated energy system

Zhongguo Jianchuan Yanjiu
ObjectiveTo resist the threats of cyber attacks on energy systems during sailing voyages, this paper proposes a distributed resilient energy management strategy for ship-integrated energy systems.
Yuxin ZHANG, Fei TENG, Tieshan LI, Yang XIAO   +3 more
doaj   +1 more source

Optimal Energy Management Strategy for Distributed Energy Resources

Energy Procedia, 2014
AbstractIn this paper, an optimal energy management model of a solar photovoltaic-diesel-battery hybrid power supply system is presented. The aim is to meet the load demand completely while satisfying the system constraints. The model proposed minimizes fuel and battery wear costs, and finds the optimal power flow taking into account photovoltaic power
Tazvinga, Henerica, Xia, Xiaohua, Zhu, Bing   +2 more
openaire   +1 more source