Results 121 to 130 of about 4,649,272 (339)
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Within the development of structural batteries, finding the optimal electrolyte composition, that is, one that offers both high ionic conductivity and mechanical stiffness, is essential.
Nicole Abdou +7 more
doaj +1 more source
Enhancing performance of advanced fuel cell design with functional energy materials and process
Nazmus Saadat +4 more
openalex +1 more source
Innovative Green Technology for Sustainable Industrial Estate Development
Sustainable industrial development requires a balance between economic growth, equity and environment. Two major components of industrial development are energy and raw materials.
P., Purwanto +2 more
core
Converting energy from fusion into useful forms
If fusion power reactors are to be feasible, it will still be necessary to convert the energy of the nuclear reaction into usable form. The heat produced will be removed from the reactor core by a primary coolant, which might be water, helium, molten ...
Harrington, C. +3 more
core +1 more source
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Comparative Assessment of Materials Used in the Construction of Passenger Cars in Terms of Energy Demand and Harmful Emission [PDF]
M. Mrozik, Agnieszka Merkisz-Guranowska
openalex +1 more source
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
Anecdotes and guidance notes: surviving and thriving as a woman in science
Women have overtaken men in academic engagement and achievement at virtually all levels of secondary and tertiary education. However, despite numerous initiatives over several decades, women currently comprise only a fraction (13%–28%, depending on the ...
B Gaggio +4 more
doaj +1 more source

