Results 121 to 130 of about 4,710,269 (297)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Structural Battery Electrolytes Based on a Cross‐Linked Methacrylate Polymer and a Protic Ionic Liquid: Is There an Optimal Composition?

Advanced Energy & Sustainability Research
Within the development of structural batteries, finding the optimal electrolyte composition, that is, one that offers both high ionic conductivity and mechanical stiffness, is essential.
Nicole Abdou, Achilleas Pipertzis, Richa Chaudhary, Lars Evenäs, Johanna Xu, Leif E. Asp, Jan Swenson, Anna Martinelli   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Graphite and Hexagonal Boron-Nitride Possess the Same Interlayer Distance. Why?

, 2011
Graphite and hexagonal boron nitride (h-BN) are two prominent members of the family of layered materials possessing a hexagonal lattice. While graphite has non-polar homo-nuclear C-C intra-layer bonds, h-BN presents highly polar B-N bonds resulting in ...
Alem N., Barone V., Baskin Y., Becke A. D., Benedict L. X., Bernal J. D., Björk J., Borwein D., Borwein D., Boys S. F., Buldum A., Carlson A., Castro Neto A. H., Catellani A., Chakarova-Kack S. D., Charlier J.-C., Chu X., Chung D., Cumings J., De Leeuw S. W., Dean C. R., Ding X., Ewald P. P., Ezawa M., Fan Y., Fernandez-Rossier J., Frisch M. J., Fumi F. G., Geim A. K., Ghosh P. N., Giovannetti G., Girifalco L. A., Gorbachev R. V., Green J. F., Han W.-Q., Hanke F., Hariharan P. C., Hasegawa M., Hirshfeld F. L., Hod O., Hod O., Hod O., Iijima S., Jin C., Kern G., Kganyago K. R., Kolmogorov A. N., Kuzuba T., Lebegue S., Lee C., Lennard-Jones J. E., Liu L., Liu Z., Lomer W. M., Lopatin V. V., Marini A., Marom N., Marom N., Marom N., Marom N., Meyer J. C., Mosuang T. E., Muramatsu Y., Natan A., Novoselov K. S., Novoselov K. S., Oded Hod, Onodera T., Onodera T., Ooi N., Ortmann F., Pacile D., Palser A. H. R., Parry D. E., Paszkowicz W., Pease R., Perdew J. P., Qi Y., Ren X., Ribeiro R. M., Rydberg H., Rydberg H., Shemella P., Shi Y., Simon S., Slawinska J., Solozhenko V. L., Song L., Spanu L., Taylor R., Tkatchenko A., Topsakal M., Toukmaji A. Y., Vernov A., Warner J. H., Xue J., Yamamura S., Zacharia R., Zeng H., Zhao Y., Zhao Y., Zhi C., Zobelli A., Zucker I. J., Zunger A.   +104 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Anecdotes and guidance notes: surviving and thriving as a woman in science

JPhys Energy
Women have overtaken men in academic engagement and achievement at virtually all levels of secondary and tertiary education. However, despite numerous initiatives over several decades, women currently comprise only a fraction (13%–28%, depending on the ...
B Gaggio, E H Driscoll, F C J Robinson, J Singleton, J L MacManus-Driscoll   +4 more
doaj   +1 more source

Converting energy from fusion into useful forms

, 2013
If fusion power reactors are to be feasible, it will still be necessary to convert the energy of the nuclear reaction into usable form. The heat produced will be removed from the reactor core by a primary coolant, which might be water, helium, molten ...
Harrington, C., Jenkins, I., Kiely, C., Kovari, M.   +3 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Optimization of scanner parameters for dual energy micro-CT [PDF]

, 2015
Two materials of different composition can have very similar grey values in an X-ray Computed Tomography (CT). This is because X-ray CT uses polychromatic sources in combination with energy-integrating detectors and the materials have a mass attenuation ...
De Muynck, Amélie, Dhaene, Jelle, Dierick, Manuel, Pauwels, Elin, Van Hoorebeke, Luc   +4 more
core