Results 141 to 150 of about 8,773,144 (338)

Towards energy-performance trade-off analysis of parallel applications [PDF]

, 2011
"Energy consumption by computer systems has emerged as an important concern, both at the level of individual devices (limited battery capacity in mobile systems) and at the societal level (the production of Green House Gases).
Korthikanti, Vijay Anand R., Korthikanti, Vijay Anand   +1 more
core  

Energy-Based Metrics for General Aviation Flight Data Record Analysis [PDF]

, 2016
Energy management and energy state awareness are important concepts in aircraft safety analysis. Many loss-of-control accidents can be attributed to poor energy management.
Tejas G. Puranik, Dimitri N. Mavris, Harrison, Evan D., Jimenez, Hernando, Mavris, Dimitri N., Sanggyu Min, Hernando Jimenez, Min, Sanggyu, Evan Harrison, Puranik, Tejas G.   +9 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

User's Guide to the Energy Charting and Metrics Tool (ECAM) [PDF]

, 2012
The intent of this user guide is to provide a brief description of the functionality of the Energy Charting and Metrics (ECAM) tool, including the expanded building re-tuning functionality developed for Pacific Northwest National laboratory (PNNL).
Koran, William, Taasevigen, Danny J.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Robustness and resilience of energy systems to extreme events: A review of assessment methods and strategies

Energy Strategy Reviews
This comprehensive review investigates the robustness and resilience of energy systems in response to extreme events, emphasizing the need for enhanced methodologies and strategies to mitigate the growing vulnerabilities in modern power grids.
Kasra Shafiei, Saeid Ghassem Zadeh, Mehrdad Tarafdar Hagh   +2 more
doaj   +1 more source

Characterization of the energy-dependent uncertainty and correlation in silicon neutron displacement damage metrics

EPJ Web of Conferences, 2017
A rigorous treatment of the uncertainty in the underlying nuclear data on silicon displacement damage metrics is presented. The uncertainty in the cross sections and recoil atom spectra are propagated into the energy-dependent uncertainty contribution in
Griffin Patrick, Rochman Dimitri, Koning Arjan   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Renewable export cost index as an indicator of global renewable energy trade potential

Communications Earth & Environment
Renewable energy resources are widely available, yet they are unevenly distributed globally. In a renewable future, countries lacking high-quality renewable resources may choose to import energy from other countries.
Xiaoming Kan, Lina Reichenberg, Fredrik Hedenus, David Daniels   +3 more
doaj   +1 more source